ADAM8在恶性肿瘤转移中的作用研究进展

发布时间：2018-03-21 22:26

本文选题：肿瘤　切入点：肿瘤转移　出处：《中国药理学通报》2017年08期 　论文类型：期刊论文

【摘要】：转移是恶性肿瘤的重要生物学特征之一,与肿瘤患者的预后紧密相关。近年来研究表明,去整合素-金属蛋白酶8(a disintegrin and metalloprotease 8,ADAM8)在多种恶性肿瘤中呈现高表达状态,且在恶性肿瘤的转移中发挥着重要的作用。研究显示,ADAM8过表达可减弱肿瘤细胞间的黏附作用,并促进细胞外基质(extracellular matrix,ECM)降解和细胞膜上细胞因子释放,同时有助于肿瘤部位新生血管生成,从而促进了肿瘤细胞转移。因此,抑制ADAM8有可能对肿瘤转移产生抑制作用,这使得ADAM8成为恶性肿瘤的预后指标和潜在治疗靶点,备受关注。该文对ADAM8与肿瘤转移的研究进展进行综述,探讨ADAM8介导的肿瘤转移的机制和靶向ADAM8进行肿瘤转移治疗的策略,为后续研究和临床治疗提供重要的参考。
[Abstract]:Transfer is one of the important biological characteristics of malignant tumors, is closely related with the prognosis of patients with cancer. Recent studies show that a disintegrin and metalloproteinase 8 (a disintegrin and metalloprotease 8, ADAM8) showed high expression in a variety of malignant tumors, and metastasis of malignant tumor plays an important role. The research shows. Overexpression of ADAM8 can decrease the adhesion of tumor cells, and promote extracellular matrix (extracellular matrix, ECM) on the cell membrane degradation and release of cytokines, and contribute to tumor angiogenesis formation, thereby promoting the metastasis of tumor cells. Therefore, inhibition of ADAM8 may have inhibitory effect on the tumor metastasis. Make ADAM8 become a prognostic marker of malignant tumor and the potential therapeutic targets of concern. The research progress of ADAM8 and tumor metastasis were reviewed, to investigate the ADAM8 mediated tumor The mechanism of metastasis and the strategy of targeting ADAM8 for tumor metastasis provide important reference for follow-up study and clinical treatment.

【作者单位】：南京中医药大学药学院;江苏省中药药效与安全性评价重点实验室;江苏省中医药防治肿瘤协同创新中心;
【基金】：国家自然科学基金项目资助(No 81673725,81673648,81573859) 江苏省自然科学基金资助项目(No BK2012854)
【分类号】：R730.2

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