COX-2、MMP-9与PTEN在结肠腺癌组织中的表达及意义

发布时间：2018-03-21 22:26

本文选题：基质金属蛋白酶-　切入点：结肠腺癌　出处：《重庆医学》2017年33期 　论文类型：期刊论文

【摘要】：目的探讨环氧合酶-2(COX-2)、基质金属蛋白酶-9(MMP-9)和PTEN在结肠腺癌组织中的表达及意义。方法收集该院2014年3月至2016年5月结肠腺癌根治术后病理存档的石蜡标本72例,30例结肠腺瘤组织及30例正常结肠黏膜组织为对照。采用免疫组化SP法检测COX-2、MMP-9和PTEN的表达情况,分析COX-2、MMP-9和PTEN与结肠腺癌临床病理特征的相关性。结果 COX-2、MMP-9在结肠腺癌组织中表达阳性率明显高于结肠腺瘤组织、正常结肠黏膜组织(P0.05),PTEN的表达阳性率明显低于结肠腺瘤组织、正常结肠黏膜组织(P0.05)。COX-2、MMP-9和PTEN在结肠腺癌的表达与肿瘤浸润深度、有无淋巴结转移及TNM分期相关(P0.05),与性别、年龄、肿瘤形态、肿瘤直径、分化程度无关(P0.05)。COX-2、MMP-9与PTEN表达均呈负相关(r=-0.260、-0.282,P0.05),COX-2与MMP-9表达呈正相关(r=0.335,P0.05)。结论COX-2、MMP-9与PTEN的异常表达和相互作用与结肠腺癌的发生、侵袭转移密切相关,联合检测对结肠腺癌早期诊断、预后评估具有重要意义。
[Abstract]:Objective to investigate the expression and significance of cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9) and PTEN in colonic adenocarcinoma. Methods from March 2014 to May 2016, 72 cases of paraffin wax specimens of colon adenocarcinoma after radical resection were collected. The expression of COX-2 MMP-9 and PTEN in colon adenoma and 30 normal colonic mucosa were detected by immunohistochemical SP method. Results the positive rate of COX-2 MMP-9 and PTEN in colonic adenocarcinoma was significantly higher than that in colonic adenoma, and the positive rate of P0.05PTEN in normal colonic mucosa was significantly lower than that in colonic adenoma. The expression of MMP-9 and PTEN in normal colonic mucosa was correlated with the depth of tumor invasion, lymph node metastasis and TNM staging, and was associated with sex, age, tumor morphology, tumor diameter. The expression of COX-2 and MMP-9 was positively correlated with the expression of COX-2 and MMP-9. Conclusion the abnormal expression and interaction between COX-9 and PTEN are closely related to the occurrence, invasion and metastasis of colon adenocarcinoma. Prognostic evaluation is of great significance.
【作者单位】：河北省保定市第一医院普外科;
【分类号】：R735.35

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