富含半胱氨酸分泌性酸性蛋白在乳腺癌组织中的表达及其临床意义

发布时间：2018-03-21 23:34

本文选题：半胱氨酸的分泌性酸性蛋白　切入点：乳腺肿瘤　出处：《中国临床药理学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的观察富含半胱氨酸分泌性酸性蛋白(SPARC)在人乳腺癌组织中的表达及其与患者临床病理特征和预后的关系。方法选取122例乳腺癌患者的完整肿瘤组织蜡块为研究对象,用免疫组化法检测癌组织中SPARC的表达水平,并分析其与临床病理特征及预后的关系。结果 SPARC主要表达于乳腺癌组织的细胞质和细胞间质,并弥漫分布,呈现深棕紫色颗粒状。SPARC在乳腺癌组织中的阳性表达率为72.13%(88/122例)。SPARC在乳腺组织中的阳性表达与患者的年龄、月经状况、TNM分期、肿瘤大小、孕激素水平、人类表皮生长因子受体2(HER-2)无明显相关性(P0.05),与肿瘤分化程度、雌激素受体水平及淋巴结转移存在明显相关性(P0.05)。SPARC阳性和阴性组3年无疾病进展生存率分别为69.92%和86.13%,差异有统计学意义(P0.05)。结论 SPARC与乳腺癌的发生发展密切相关,且与雌激素受体水平及淋巴结转移有关,可作为乳腺癌复发的肿瘤标志物。
[Abstract]:Objective to observe the expression of cysteine-rich secretory acid protein Sparc in human breast cancer and its relationship with clinicopathological features and prognosis. The expression of SPARC was detected by immunohistochemical method, and its relationship with clinicopathological features and prognosis was analyzed. Results SPARC was mainly expressed in the cytoplasm and interstitial of breast cancer, and was diffusely distributed. The positive expression rate of SPARC in breast cancer tissues was 72.1388 / 122 and the age, menstrual status, tumor size, progesterone level of the patients. There was no significant correlation between human epidermal growth factor receptor 2 (HER-2) and tumor differentiation. There was a significant correlation between estrogen receptor level and lymph node metastasis. The 3-year disease-free survival rate was 69.92% in the positive group and 86.13% in the negative group, and the difference was statistically significant (P 0.05). Conclusion SPARC is closely related to the occurrence and development of breast cancer. Estrogen receptor level and lymph node metastasis may be used as tumor markers for breast cancer recurrence.
【作者单位】：丽水市中心医院甲状腺乳腺外科;
【基金】：浙江省丽水市科技基金项目资助(2013KZ28)
【分类号】：R737.9

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