G1与G2级胰腺神经内分泌肿瘤CT影像学特征比较分析

发布时间：2018-03-24 21:41

本文选题：胰腺　切入点：神经内分泌肿瘤　出处：《中国实用外科杂志》2017年05期

【摘要】：目的对比分析G1与G2级胰腺神经内分泌肿瘤(pNENs)的术前CT影像特征,探讨其对pNENs病理学分级潜在的诊断价值。方法回顾性分析2010年1月至2015年12月第二军医大学附属长征医院和第二军医大学附属长海医院行动态CT增强扫描并手术切除的56例pNENs病例术前CT图像资料,比较G1与G2级pNENs病人的CT影像学特征,并通过ROC曲线分析肿瘤病灶CT绝对与相对强化值在鉴别G1与G2级病人中的诊断价值。结果 G2级pNENs病人的肿瘤最大径显著大于G1级病人[(4.2±3.3)cm vs.(3.0±1.4)cm,P=0.04],G2级病人发生浸润生长的比例显著高于G1级病人[(17/12)vs.(6/21),P0.01]。CT影像学特征分析发现G1级病人动脉期、门静脉期的肿瘤绝对和相对强化程度及延迟期的肿瘤绝对强化程度均高于G2级病人(P0.01)。ROC曲线分析发现门静脉期绝对强化值的ROC曲线下面积(AUC)达0.811(95%CI 0.700~0.922),特异度为0.655,敏感度为0.889。结论 G1与G2级pNENs病人具有不同的CT影像学特征,动脉期、门静脉期的肿瘤绝对和相对强化程度及延迟期的肿瘤绝对强化程度等可以用于术前判断G1与G2级pNENs。
[Abstract]:Objective to compare and analyze the features of pNENNs in G1 and G2 grade pancreatic neuroendocrine tumors before operation. To explore the potential diagnostic value of pNENs pathological grading. Methods from January 2010 to December 2015, dynamic CT enhanced scanning and surgery were performed in the long March Hospital affiliated to the second military Medical University and the Changhai Hospital affiliated to the second military Medical University. Ct images of 56 cases of pNENs resected before operation were analyzed. Ct imaging features of G1 and G2 grade pNENs patients were compared. The diagnostic value of absolute and relative enhancement values of CT in differentiating G1 and G2 grade patients was analyzed by ROC curve. Results the maximum diameter of tumor in G2 grade pNENs patients was significantly larger than that in G1 grade patients [4.2 卤3.3)cm vs.(3.0 卤1.4 cm P0. 04] G2-grade patients developed infiltration and growth. The proportion of patients with grade G 1 was significantly higher than that of patients with grade G 1 [17 / 12 vs.6 / 21 / P0.01]. Ct imaging analysis showed that the arterial phase of patients with grade G 1 was significantly higher than that of patients with grade G 1. The absolute and relative enhancement degree of portal vein tumor and the absolute enhancement degree of tumor in delayed phase were higher than those in G2 grade patients. The area under the ROC curve of absolute enhancement value of portal vein phase was 0.700 and 0.922, and the specificity was 0.655 and sensitive. Conclusion G1 and G2 pNENs patients have different CT imaging features. The absolute and relative enhancement degree of tumor in arterial phase, portal vein phase and the absolute enhancement degree of tumor in delayed phase can be used to judge G1 and G2 pNENs before operation.
【作者单位】：第二军医大学附属长征医院普外科;第二军医大学附属长海医院影像科;
【分类号】：R735.9

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