临床前癌症模型的研究进展

发布时间：2018-03-28 16:29

本文选题：肿瘤　切入点：小鼠　出处：《肿瘤》2017年08期

【摘要】：随着癌症发生率和死亡率的逐年上升,癌症已成为威胁人类健康的首要敌人,因此越来越多的研究者投入癌症发病机制及新疗法的探索之中。尽管如此,每年仍然只有屈指可数的抗癌新药通过审批,究其原因主要是绝大多数具有较好临床前效应的新药缺乏良好的临床疗效,因此合理应用及创新临床前抗肿瘤药物的评价体系,促进临床前研究与临床药效的结合与统一,就显得尤为迫切和重要。众所周知,动物癌症模型在癌症的病因和发病机制研究以及治疗评估中发挥着举足轻重的作用。本文对最为常用的小鼠癌症模型在临床前研究中的发展前景以及面临的挑战进行了探讨,并对新兴癌症模型的应用前景进行了简述,为临床前合理评价药物疗效提供参考。
[Abstract]:With the increasing incidence and mortality rate of cancer, cancer has become the primary threat to human health, so more and more researchers are exploring the mechanism of cancer and new therapies. Only a handful of new anticancer drugs are approved each year. The main reason is that most of the new drugs with good preclinical effects lack good clinical efficacy. Therefore, the rational application and innovation of the evaluation system of pre-clinical anti-tumor drugs, It is particularly urgent and important to promote the combination and unification of preclinical research and clinical efficacy. Animal cancer models play an important role in the study of the etiology and pathogenesis of cancer, as well as in the evaluation of treatment. In this paper, the development prospects and challenges of the most commonly used mouse cancer models in preclinical research are discussed. The application prospect of the new cancer model is briefly described, which provides a reference for the rational evaluation of the efficacy of drugs before clinical treatment.
【作者单位】：南京中医药大学药学院江苏省中药药效与安全性评价重点实验室;南京中医药大学江苏省中医药防治肿瘤协同创新中心;
【基金】：国家自然科学基金资助项目(编号:81673725、81673648) 中国博士后科学基金面上资助项目(编号:2014M551639) 江苏省自然科学基金面上研究项目(编号:BK2012854) 江苏高校优势学科建设工程一期项目 2013年度江苏高校优秀科技创新团队~~
【分类号】：R-332;R73-3

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