口腔癌前哨淋巴结活检价值的系统评价

发布时间：2018-03-29 05:12

本文选题：口腔癌　切入点：前哨淋巴结　出处：《实用口腔医学杂志》2017年01期

【摘要】：目的:探讨前哨淋巴结活检(SLNB)对于判断口腔癌颈淋巴结转移的敏感性和特异性及临床预测价值。方法:计算机检索PubMed、EMBASE、CENTRAL、中国期刊全文、万方、中国生物医学文献等相关数据库,搜集已公开发表的有关SLNB预测口腔癌颈淋巴结转移的相关诊断试验,应用Meta-disc 1.4统计软件进行分析,评价SLNB预测口腔癌颈淋巴结转移敏感性、特异性和受试者工作特征曲线(ROC)下面积(AUC)。结果:最终共25项诊断实验、934例受试者纳入本研究。Meta分析结果显示SLNB预测口腔癌颈淋巴结转移敏感性和特异性分别为91%(95%CI 88%-94%)和100%(95%CI 99%-100%);综合受试者工作特征曲线(SROC)下面积(AUC)为0.99。结论:SLNB预测口腔癌颈淋巴结转移敏感性、特异性均较高,作为判断颈淋巴结转移的标准有较高的临床应用价值。
[Abstract]:Objective: to investigate the sensitivity, specificity and clinical predictive value of sentinel lymph node biopsy (SLNB) in the diagnosis of cervical lymph node metastasis in oral cancer. Methods: the relevant databases of PubMedus EMBASEN CENTRAL, full text of Chinese Journal, Wanfang and Chinese Biomedical Literature were searched by computer. The related diagnostic tests of SLNB for predicting cervical lymph node metastasis of oral carcinoma were collected and analyzed by Meta-disc 1.4 software to evaluate the sensitivity of SLNB in predicting cervical lymph node metastasis of oral carcinoma. Results: a total of 934 patients with 25 diagnostic experiments were included in the present study. Meta-analysis showed that the sensitivity and specificity of SLNB in predicting cervical lymph node metastasis in oral cancer were 91%(95%CI, respectively. The area under the operating characteristic curve of the subjects is 0.99.Conclusion the sensitivity of 100%(95%CI in predicting cervical lymph node metastasis in oral cancer is 0.99.Conclusion the sensitivity of 100%(95%CI in predicting cervical lymph node metastasis in oral carcinoma is 0.99. The specificity of cervical lymph node metastasis is high, and it has high clinical application value as a criterion of cervical lymph node metastasis.
【作者单位】：大理学院附属医院口腔科;普洱市郭强口腔诊所;昆明医科大学附属口腔医院;
【基金】：国家自然科学基金(编号:30960422,81160325) 云南省自然科学基金(编号:2009CC021)
【分类号】：R739.8

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