靶向白血病干细胞的研究进展

发布时间：2018-04-01 00:09

本文选题：白血病干细胞　切入点：靶向治疗　出处：《中国科学:生命科学》2017年12期

【摘要】：白血病是一种造血系统的恶性肿瘤性疾病,目前的治疗手段以化疗为主,还包括给药控制,骨髓移植等常规疗法.但传统的化疗方法副作用大,在杀伤白血病细胞的同时也会损伤机体正常细胞,降低患者的生活质量.并且因为白血病干细胞(leukemia stem cells,LSCs)的存在,使得传统治疗方法难以根治白血病.目前学者普遍认为LSCs是引起白血病的根源,也是其易于复发的主要原因.因此寻找靶向清除LSCs的有效方法,在降低对机体正常细胞的损伤的同时治疗疾病,延长患者生命是十分必要的.本文介绍了LSCs的主要生物学特征,以及以此为基础而实现靶向杀伤白血病干细胞的方法,并就靶向白血病干细胞自我更新与凋亡通路,表面免疫受体,生存微环境等方面的分子机制进行综述.
[Abstract]:Leukemia is a malignant disease of hematopoietic system. At present, chemotherapy is the main treatment, including administration control, bone marrow transplantation and other routine therapy.However, the traditional chemotherapy method has great side effects, which can injure the normal cells and reduce the quality of life of the patients while killing leukemia cells.Because of the existence of leukemia stem cells, it is difficult to cure leukemia by traditional methods.At present, it is generally believed that LSCs is the root cause of leukemia and the main reason for its recurrence.Therefore, it is necessary to search for an effective method to remove LSCs, to reduce the damage to normal cells and to treat diseases and prolong the life of patients.In this paper, the main biological characteristics of LSCs and the methods of targeting leukemia stem cells were introduced, and the self-renewal and apoptosis pathway of targeted leukemic stem cells, the surface immune receptors were also discussed.The molecular mechanisms of microenvironment are reviewed.
【作者单位】：中国医学科学院&北京协和医学院血液病医院(血液学研究所);
【基金】：国家自然科学基金(批准号:81600085) 中国医学科学院医学与健康科技创新工程项目(批准号:2016-12M-1-017)资助
【分类号】：R733.7

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