原始神经外胚层肿瘤52例的临床特征及预后

发布时间：2018-04-01 00:21

  本文选题：原始神经外胚层肿瘤　切入点：发病特征　出处：《实用医学杂志》2017年15期

【摘要】：目的探讨原始神经外胚层肿瘤(PNET)的临床特征及预后。方法收集2011年3月至2015年3月确诊的PNET患者临床资料,共52例,总结其临床特点及治疗情况。计算总体1、2、3年生存率,中位无疾病进展期(PFS)和中位生存期(OS);单因素生存分析用K-M法,多因素分析用COX回归;分析不同预后因素对OS的影响。结果 CD99、FLI-1是诊断PNET重要免疫组化指标,阳性率分别为95.9%,95.0%。EWSR1基因检测可提高PNET诊断的特异性和敏感度,阳性率85.7%。总体中位PFS 10月,中位OS 18月,1、2、3年生存率分别为76.9%、42.6%、17.7%。单因素分析:OS与肿瘤位置、分期、治疗方案相关,而与发病年龄、性别无关。COX多因素分析:肿瘤位置、分期和治疗方案是影响预后的独立因素。结论Ⅰ~Ⅱ期,肿瘤位于非中线部位,采用手术、放疗、化疗综合治疗的患者预后好。
[Abstract]:Objective to investigate the clinical features and prognosis of primitive neuroectodermal tumor (PNET). Methods 52 patients with PNET diagnosed from March 2011 to March 2015 were collected and their clinical characteristics and treatment were summarized. COX regression was used for univariate survival analysis and COX regression for multivariate analysis, and the influence of different prognostic factors on OS was analyzed. Results CD99 FLI-1 was an important immunohistochemical index in the diagnosis of PNET. The positive rate of EWSR1 gene was 95.9% and 95.0%, respectively. The positive rate was 85.7%. The overall median PFS in October, the median OS in 18 months and the 3-year survival rate were 76.9% and 42.6%, respectively. Univariate analysis showed that the positive rate was related to tumor location, stage, and treatment plan. Cox multivariate analysis showed that tumor location, stage and treatment regimen were independent factors affecting prognosis. Conclusion in stage 鈪，

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