子宫内膜癌标志物表达及其临床意义研究

发布时间：2018-04-01 19:44

  本文选题：子宫内膜癌　切入点：免疫组织化学　出处：《中国实用妇科与产科杂志》2017年06期

【摘要】：目的探讨p53、磷酸酶与张力蛋白同源物(PTEN)、p16、人类表皮生长因子受体-2(HER-2)、Ki67的表达及其与子宫内膜癌发生发展的相关性。方法采用免疫组织化学法检测上海市普陀区妇婴保健院病理科2009月1年至2015年12月确诊的50例正常子宫内膜组织、20例不典型增生子宫内膜组织及75例子宫内膜癌中p53、PTEN、p16、HER-2及Ki67的表达,并对不同子宫内膜组织的表达结果进行比较。结果 p53、PTEN、p16、HER-2和Ki67在正常子宫内膜和子宫内膜癌中的表达差异均有统计学意义(P0.05),在不典型增生子宫内膜中HER-2和Ki67表达显著高于正常子宫内膜(P0.05),子宫内膜癌与不典型增生子宫内膜中PTEN、Ki67的表达差异有统计学意义(P0.05)。在Ⅰ型和Ⅱ型子宫内膜癌之间p53、PTEN、p16、HER-2表达差异有统计学意义(P0.05),Ki67在Ⅰ型和Ⅱ型子宫内膜癌间表达相近(P0.05)。p53在子宫内膜癌的表达率与肿瘤的分化程度、浸润深度、脉管情况及临床分期密切相关(P0.05),而PTEN、p16、HER-2和Ki67的表达与这些临床病理特征无关(P0.05)。结论 p53、PTEN、p16、HER-2和Ki67蛋白的表达与子宫内膜癌的发生发展相关,在实际临床工作中可用于子宫内膜病变的病理诊断。
[Abstract]:Objective to investigate the expression of p53, phosphatase and tension protein congener PTENP16, human epidermal growth factor receptor (EGF) -2HER-2HER-2Aki67 and their relationship with the occurrence and development of endometrial carcinoma. Methods Immunohistochemical method was used to detect the occurrence and development of women and infants in Putuo District, Shanghai. From 2001 to 2015, 50 cases of normal endometrial tissues and 75 cases of endometrial carcinoma with atypical hyperplasia were confirmed by Department of Pathology of Health Hospital. The expression of p53 PTENN, p16, HER-2 and Ki67 were detected. Results there were significant differences in the expression of p53 PTENN, p16, HER-2 and Ki67 in normal endometrium and endometrial carcinoma. The expressions of HER-2 and Ki67 in atypical hyperplasia endometrium were significantly higher than those in normal endometrium and endometrial carcinoma. In endometrial carcinoma and atypical hyperplasia of endometrium, there was a significant difference in the expression of PTENN Ki67 between type 鈪，

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