局部晚期胃癌术前同期放化疗的临床疗效

发布时间：2018-04-01 22:26

  本文选题：局部晚期胃癌　切入点：术前同期放化疗　出处：《广东医学》2017年03期

【摘要】：目的比较术前同期放化疗与术前化疗对局部晚期胃癌的疗效及不良反应。方法将局部晚期胃癌患者72例随机分为:术前同期放化疗组36例:顺铂+卡培他滨术前3个疗程,并与放疗同期治疗;术前化疗组36例:顺铂+卡培他滨术前3个疗程。评价两组的术后病理完全缓解(p CR)率、R0切除率及不良反应,并随访比较2年无进展生存(PFS)和2年总生存(OS)。结果术前同期放化疗组的p CR率、R0切除率和2年PFS都要优于术前化疗组(P=0.042、0.023、0.032);术前同期放化疗组的2年OS与术前化疗组差异无统计学意义(P=0.518);术前同期放化疗组发生Ⅲ度腹痛、Ⅲ度恶心呕吐、Ⅲ度白细胞下降与术前化疗组差异无统计学意义(P=0.074、0.358、0.691)。结论局部晚期胃癌术前同期放化疗比术前化疗能够获得更好的p CR、R0切除和PFS,两组不良反应相近,但术前同期放化疗不能延长OS。
[Abstract]:Objective to compare the efficacy and adverse effects of preoperative radiotherapy and chemotherapy on locally advanced gastric cancer. Methods 72 patients with locally advanced gastric cancer were randomly divided into preoperative radiotherapy and chemotherapy group (n = 36) and cisplatin capecitabine group (n = 36). 36 patients in the preoperative chemotherapy group were treated with cisplatin capecitabine for 3 courses before operation. Results the rate of pCR, R0 and PFS in the preoperative radiotherapy and chemotherapy group were higher than those in the preoperative chemotherapy group and the preoperative chemotherapy group, and the 2-year OS in the preoperative chemotherapy group and the preoperative chemotherapy group were higher than those in the preoperative chemotherapy group and the preoperative chemotherapy group respectively, and the two year OS in the preoperative radiotherapy and chemotherapy group was higher than that in the preoperative chemotherapy group and that in the preoperative chemotherapy group. There was no significant difference between the two groups, and the third degree abdominal pain occurred in the same time before the operation in the radiotherapy and chemotherapy group, and there was no significant difference between the two groups. There was no significant difference between the grade 鈪，

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