口腔鳞癌新辅助化疗前后多药耐药相关蛋白的表达及临床疗效分析

发布时间：2018-04-02 15:12

本文选题：口腔鳞癌　切入点：新辅助化疗　出处：《口腔医学研究》2017年12期

【摘要】：目的:观察口腔鳞癌患者新辅助化疗疗效与5年生存率的关系,并探讨P-gp、MRP1、GST-π与新辅助化疗疗效的关系。方法:1)收集南昌大学第一附属医院诊治的口腔鳞癌石蜡标本77例(有效组50例,无效组27例),随访5年生存时间,Envision法检测P-gp、MRP1、GST-π表达水平;2)收集本单位口腔鳞癌新鲜标本33例(有效组18例,无效组15例),qPCR、WesternBlot法检测P-gp、MRP1、GST-π表达水平。结果:1)KaplanMeier显示:有效组5年生存率高于无效组(P0.05)。2)Envision、qPCR、WesternBlot显示:无效组化疗后Pgp、MRP1表达上升量较有效组有显著差异(P0.05),而GST-π表达上升量无显著差异(P0.05)。结论:口腔鳞癌新辅助化疗有效组5年生存率明显高于无效组;化疗疗效与P-gp、MRP1表达相关,表达上升量越高,疗效越差。
[Abstract]:Objective: to investigate the relationship between the efficacy of neoadjuvant chemotherapy and 5 year survival rate in patients with oral squamous cell carcinoma (SCC), and to explore the relationship between P-gpMr MRP1GST- 蟺 and neoadjuvant chemotherapy.Methods A total of 77 cases of oral squamous cell carcinoma (OSCC) were collected from the first affiliated Hospital of Nanchang University (effective group, 50 cases).Twenty-seven cases of ineffective group were followed up for 5 years to detect the expression level of GST- 蟺 by envision method. 33 cases of oral squamous cell carcinoma were collected (18 cases of effective group and 15 cases of ineffective group) to detect the expression of GST- 蟺 in MRP1GST- 蟺 by Western Blot.Conclusion: the 5-year survival rate of neoadjuvant chemotherapy in oral squamous cell carcinoma is significantly higher than that in ineffective group, and the effect of chemotherapy is correlated with the expression of P-gpfen MRP1, and the higher the expression level is, the worse the curative effect is.
【作者单位】：南昌大学第一附属医院口腔颌面外科;
【基金】：江西省科技厅自然科学基金重大项目(编号:20152ACB20019)
【分类号】：R739.8

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