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西黄胶囊辅助放化疗治疗中晚期食管癌患者的疗效评价

发布时间:2018-04-02 23:42

  本文选题:西黄胶囊 切入点:食管肿瘤 出处:《吉林大学学报(医学版)》2017年04期


【摘要】:目的:探讨西黄胶囊辅助放化疗治疗中晚期食管癌患者的疗效及不良反应,阐明其作用机制。方法:选择未治的中晚期食管癌患者,通过筛选及剔除不满足本研究要求者,最后入组患者114例,其中接受西黄胶囊联合放化疗同期治疗的患者27例(联合治疗组);仅接受单纯放化疗治疗患者87例,随机抽取其中27例患者作为单纯放化疗组。观察时间均为放疗起始至第90天。比较2组患者生存质量评分(KPS)、吞咽困难程度及急性放射性食管炎的发生率、发生时间和严重程度分级,分析患者肿瘤局控情况。结果:治疗结束后,2组患者KPS评分均出现不同程度下降,但联合治疗组患者KPS评分明显高于单纯放化疗组(P0.05)。治疗中晚期阶段,联合治疗组患者吞咽困难程度轻于单纯放化疗组(P0.05),急性放射性食管炎的发生率亦低于单纯放化疗组(P0.05),发生时间明显迟于单纯放化疗组(P0.05),但2组患者急性放射性食管炎严重程度分级和肿瘤局控分级比较差异无统计学意义(P0.05)。结论:西黄胶囊对中晚期食管癌患者生存质量起促进作用,同时可缓解患者吞咽困难程度,降低急性放射性食管炎的发生率并延缓其发生时间,可作为中晚期食管癌患者放化疗同期治疗的良好辅助用药。
[Abstract]:Objective: to investigate the efficacy and adverse reactions of Xihuang capsule in the treatment of middle and advanced esophageal carcinoma and to elucidate its mechanism.Methods: 114 patients with advanced esophageal cancer were selected by screening and culling the patients who did not meet the requirements of this study.Among them, 27 patients were treated with Xihuang capsule combined with radiotherapy and chemotherapy (combined treatment group), 87 patients received radiotherapy and chemotherapy alone, and 27 patients were randomly selected as radiotherapy and chemotherapy group.The observation time was from the beginning of radiotherapy to the 90th day.The quality of life score (QOL), dysphagia and the incidence, time and severity of acute radiation esophagitis were compared between the two groups.Results: the KPS scores of the two groups decreased in different degrees after the treatment, but the KPS score in the combined treatment group was significantly higher than that in the radiotherapy and chemotherapy group alone (P 0.05).In the middle and late stages of treatment,The degree of dysphagia in the combined treatment group was less than that in the radiotherapy and chemotherapy group, and the incidence of acute radiation esophagitis was also lower than that in the radiotherapy and chemotherapy alone group. The time of occurrence of acute radiation esophagitis in the combined treatment group was significantly later than that in the radiotherapy and chemotherapy alone group, but the acute radioactivity in both groups was lower than that in the chemotherapy alone group.There was no significant difference between the severity grade of tracheitis and the local control grade of tumor (P 0.05).Conclusion: Xihuang capsule can promote the quality of life of patients with advanced esophageal cancer, alleviate the degree of dysphagia, reduce the incidence of acute radiation esophagitis and delay the time of occurrence.It can be used as a good adjuvant drug for radiotherapy and chemotherapy in patients with advanced esophageal cancer.
【作者单位】: 吉林大学中日联谊医院放射治疗科;
【基金】:国家自然科学基金资助课题(31600679) 吉林省科技厅社发处科研项目资助课题(20090458);吉林省科技厅自然科学基金(白求恩专项)资助课题(20160101079JC) 吉林省卫计委科研基金资助课题(2014ZC054) 吉林大学研究生创新基金资助课题(2016223);吉林大学横向资助课题(2015373)
【分类号】:R735.1

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