晚期前列腺癌不同雄激素剥夺治疗方式与继发糖尿病和糖耐量异常风险的相关性研究

发布时间：2018-04-03 17:11

本文选题：前列腺癌　切入点：雄激素剥夺治疗　出处：《山西医科大学》2017年硕士论文

【摘要】：目的探讨晚期前列腺癌(PCa)间歇性雄激素剥夺治疗(IADT)和持续性雄激素剥夺治疗(CADT)两种不同方式与继发糖尿病(DM)和糖耐量异常(IGT)风险的相关性。方法:对2013年1月至2015年12月于我院进行ADT的PCa患者进行回顾性病例对照研究。通过监测患者空腹血糖、餐后2小时血糖及口服糖耐量试验,结合患者相关临床症状,对IADT和CADT引起DM和IGT的风险进行统计学分析,并分析组内体质指数(BMI)、高血压、吸烟、饮酒等因素与继发性DM和IGT的关系。结果:IADT组53例(46.5%),平均(69.1±4.3)岁;CADT组61例(53.5%),平均(70.2±5.7)岁,两组在临床特点方面均无明显差异(p均0.05);IADT组体质指数、高血压、吸烟、饮酒等因素对DM、IGT的发生均无明显影响(p均0.05),CADT组BMI、高血压、吸烟、饮酒等因素对DM、IGT的发生均无明显影响(p均0.05);IADT组与CADT组比较,对引起DM发生无统计学差异(P=0.643);但对引起IGT发生差异有统计学意义(P=0.029)。结论:IADT与CADT相比,虽然在引起继发DM上没有差异,但是IADT降低了糖代谢紊乱的发生,把DM遏制在前期状态,在一定程度上降低了继发DM的发生,IADT安全性相对CADT高。
[Abstract]:Objective to investigate the effect of advanced prostate cancer (PCa) intermittent androgen deprivation therapy (IADT) and continuous androgen deprivation therapy (CADT) in two different ways and secondary diabetes mellitus (DM) and impaired glucose tolerance (IGT) risk correlation. Methods from January 2013 to December 2015 in our hospital ADT PCa underwent retrospective control study cases. The patients with fasting blood glucose monitoring, 2 hour postprandial blood glucose and oral glucose tolerance test combined with clinical symptoms in patients with IADT and CADT, DM and IGT of the risk caused by statistical analysis and group analysis of body mass index (BMI), hypertension, smoking, drinking and other factors and the relationship between DM and secondary IGT. Results: IADT group of 53 cases (46.5%), average (69.1 + 4.3); CADT group of 61 cases (53.5%), average (70.2 + 5.7) years old, the two groups in clinical characteristics did not differ significantly (P < 0.05); group IADT, BMI, hypertension, smoking, drinking, etc. factor For DM, had no effect on the occurrence of IGT (P 0.05), CADT group, BMI, hypertension, smoking, drinking and other factors on the DM, had no effect on the occurrence of IGT (P 0.05); IADT group compared with CADT group, the incidence of DM caused no significant difference (P=0.643); but for the cause IGT. The difference was statistically significant (P=0.029). Conclusion: IADT compared with CADT, although there is no difference in the cause of secondary DM, but IADT reduced sugar metabolic disorders, the DM containment in the early state, to a certain extent, reduce the secondary DM, IADT CADT security is relatively high.

【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.25;R587.1

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