自体树突状细胞-细胞因子诱导的杀伤细胞联合常规化疗对转移性胰腺癌的疗效分析

发布时间：2018-04-03 22:26

本文选题：胰腺肿瘤　切入点：免疫疗法　出处：《中国普通外科杂志》2017年09期

【摘要】：目的:探讨自体树突状细胞-细胞因子诱导的杀伤细胞(DC-CIK)联合常规化疗治疗转移性胰腺癌患者的近、远期效果。方法:选取96例转移性胰腺癌患者随机分为对照组与观察组,每组各48例,对照组患者行单纯替吉奥化疗,观察组在替吉奥化疗的基础上联合使用自体DC-CIK治疗,比较两组的近期(两个疗程后)疗效与远期预后。结果:对照组与观察组的缓解率差异无统计学意义(39.58%vs.27.08%,P0.05),但总有效率明显升高(77.08%vs.58.33%,P0.05);两组治疗前T淋巴细胞亚群、IFN-γ与IL-4水平差异均无统计学意义(均P0.05),治疗后,观察组CD3~+细胞、CD4~+细胞、CD4~+/CD8~+比值、IFN-γ水平明显高于对照组(P0.05),CD8~+细胞、IL-4水平明显低于对照组(P0.05)。两组患者的治疗过程中各毒副反应的发生率无明显差异(均P0.05)。观察组患者平均生存期与1、2、3年生存率均明显高于对照组(15.0个月vs.10.0个月;66.67%、29.17%、8.33%vs.43.75%、10.42%、0,均P0.05)。结论:自体DC-CIK联合常规化疗对转移性胰腺癌患者近期疗效、远期预后均具有改善作用。
[Abstract]:Aim: to investigate the short-term and long-term effects of autologous dendritic cell-cytokine induced killer cell DC-CIK combined with conventional chemotherapy in the treatment of metastatic pancreatic cancer.Methods: 96 patients with metastatic pancreatic cancer were randomly divided into control group (n = 48) and observation group (n = 48).The short-term effect (after two courses of treatment) and long-term prognosis were compared between the two groups.The level of IFN- 纬 was significantly higher in the observation group than in the control group. The level of IL-4 was significantly lower in the observation group than in the control group.There was no significant difference in the incidence of side effects between the two groups (P 0.05).The mean survival time, 1-, 3-year survival rate of the patients in the observation group were significantly higher than those in the control group (15.0 vs.10.0 months, 66.6729. 17 and 8.33vs.43.75vs.43.75vs.10.42, all P 0.05).Conclusion: autologous DC-CIK combined with conventional chemotherapy can improve the short-term curative effect and long-term prognosis of metastatic pancreatic cancer.
【作者单位】：广州医科大学附属肿瘤医院放疗科;广州医科大学附属肿瘤医院腹外科;
【分类号】：R735.9

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