肺癌组织中干细胞转录因子Sox2和Oct4表达与微血管密度的相关性

发布时间：2018-04-03 23:22

  本文选题：肺肿瘤　切入点：SOXB转录因子　出处：《中国组织工程研究》2017年13期

【摘要】：背景:研究已证实干细胞转录因子Sox2和Oct4的高表达与肺癌的发生密切相关。目的:探讨肺癌组织中Sox2和Oct4表达与肿瘤微血管生成、临床病理指标的相关性。方法:应用免疫组织化学染色法检测60例肺癌组织和60例正常组织中Sox2和Oct4的表达,以及CD34标记的微血管密度。分析Sox2,Oct4的表达和微血管密度值与临床病理参数关系。结果与结论:(1)Sox2和Oct4在肺癌组织中阳性表达率为46.67%(28/60)、71.67%(43/60),而在正常肺组织中表达均为阴性,差异有显著性意义(P0.001);(2)肺癌组织中微血管密度值为16.22±2.18,明显高于正常组织4.36±2.07,差异有显著性意义(P0.001);(3)Sox2、Oct4和微血管密度均与肿瘤TNM分期、分化程度、脉管浸润、淋巴结转移及肝转移相关(P均0.05),而与年龄、性别无关(P均0.05);(4)肺癌组织Sox2和Oct4阳性表达组微血管密度值显著高于阴性组(P0.001);(5)Spearmen相关分析显示:肺癌组织中Sox2与Oct4无明显相关性(r=2.752,P0.05);(6)结果表明,Sox2和Oct4表达上调可作为肺癌发生的早期预警事件,并与微血管密度呈正相关,二者可能共同参与了肿瘤微血管的生成、浸润及血行转移。
[Abstract]:Background: the high expression of stem cell transcription factor Sox2 and Oct4 has been confirmed to be closely related to the occurrence of lung cancer.Objective: to investigate the correlation between the expression of Sox2 and Oct4 and tumor microangiogenesis and clinicopathologic indexes in lung cancer.Methods: immunohistochemical staining was used to detect the expression of Sox2 and Oct4 and the microvessel density of CD34 in 60 cases of lung cancer and 60 cases of normal tissues.The expression of Sox2 Oct4 and the relationship between microvessel density and clinicopathologic parameters were analyzed.Results and conclusion the positive expression rate of Sox2 and Oct4 in lung cancer tissues was 46.67% and 71.67% / 60% respectively, but negative in normal lung tissues.The microvessel density in lung cancer tissues was 16.22 卤2.18, which was significantly higher than that in normal tissues (4.36 卤2.07).Lymph node metastasis and liver metastasis were correlated with P 0.05, and with age.鎬у埆鏃犲叧(P鍧，

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