DC-CIK免疫治疗对卵巢癌患者凝血功能及D-二聚体水平的影响

发布时间：2018-04-04 16:20

本文选题：卵巢肿瘤　切入点：树突状细胞诱导的杀伤细胞　出处：《吉林大学学报(医学版)》2017年01期

【摘要】：目的:探讨树突状细胞诱导的杀伤细胞(DC-CIK)免疫治疗前后卵巢癌患者凝血功能指标及D-二聚体水平的变化,并阐明其临床意义。方法:选择行DC-CIK治疗的40例卵巢癌患者,在粒细胞集落刺激因子(G-CSF)动员前5d及DC-CIK免疫治疗1个月后行凝血功能各指标及D-二聚体水平的检测。比较卵巢癌患者DC-CIK免疫治疗前后凝血功能及D-二聚体水平的差异。结果:DC/CIK细胞回输后卵巢癌患者D-二聚体水平从1 063μg·L~(-1)降至485μg·L~(-1),纤维蛋白原(FIB)水平降低10%,DC/CIK治疗前后D-二聚体和FIB水平比较差异有统计学意义(P0.05)。在Ⅳ期卵巢癌患者及60岁卵巢癌患者中D-二聚体和FIB水平降低程度更为明显。与治疗前比较,治疗后D-二聚体水平正常(243μg·L~(-1))患者比例明显增加(P0.05)。结论:DC-CIK免疫治疗可通过降低卵巢癌患者的D-二聚体及FIB水平,降低其静脉血栓风险。
[Abstract]:Objective: to investigate the changes of coagulation function and D-dimer level in ovarian cancer patients before and after immunotherapy with dendritic cell-induced killer cells (DC-CIK), and to elucidate its clinical significance.Methods: 40 patients with ovarian cancer treated with DC-CIK were examined for coagulation function and D-dimer level 5 days before the mobilization of granulocyte colony stimulating factor (G-CSF) and 1 month after DC-CIK immunotherapy.To compare the coagulation function and D-dimer level of ovarian cancer patients before and after DC-CIK immunotherapy.Results the level of D- dimer in ovarian cancer patients decreased from 1 063 渭 g / L to 485 渭 g / L, and the level of fibrinogen was decreased by 10% DC- / CIK. There was a significant difference between D- dimer and FIB levels before and after treatment (P0. 05).The decreased levels of D-dimer and FIB were more significant in stage IV ovarian cancer and 60-year-old ovarian cancer patients.Compared with before treatment, the proportion of patients with normal D-dimer level (243 渭 g / L) increased significantly after treatment (P 0.05).Conclusion: the level of D-dimer and FIB in ovarian cancer patients can be reduced by w-DC-CIK immunotherapy, and the risk of venous thrombosis can be reduced.
【作者单位】：首都医科大学附属北京世纪坛医院急诊科;吉林大学中日联谊医院妇产科;
【基金】：吉林省科技厅科研基金资助课题(20150414036GH)
【分类号】：R737.31

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