肿瘤新生血管及分子靶向治疗新策略

  本文关键词：肿瘤新生血管及分子靶向治疗新策略，由笔耕文化传播整理发布。

靶向制剂,靶向制剂研究,靶向性药物,靶向性药物评价

Progenitors

Primitivevascularnetwork

Capilary

Maturevascularnetwork

Vein

图1血管发生和血管生成血管发生：内皮前体细胞形成一个原始的血管网络。血管生成：原始血

管网扩张，形成动脉、静脉和毛细血管周细胞和平滑肌细胞环绕形成完整的新生血管(图引自[4]并得到许可)

Fig.1ThedevelopmentofthevascularsystemsDuringvasculogenesis,endothelialprogenitors

giverisetoaprimitivevascularlabyrinthofarteresandveins;duringsubsequentangiogenesis,thenetworkexpands,pericytes(PCs)andsmoothmusclecells(SMCs)covernascentendothelialchannels,andastereotypicallyorganizedvascularnetworkemerges(FiguretakenfromRef.4withpermissionfromthepublisher)

皮细胞从静止状态变成具有迁移能力的顶细胞(tipcell)，同时激活间质金属蛋白酶(matrixmetalloproteinase，MMP2或MMP9)降解血管外基质，帮助顶细胞向周围扩增和迁移形成柱状丝状伪足，并逐步形成血管腔(lumen)。最后，周细胞(pericytecell，PC)和血管平滑肌细胞(vascularsmoothmusclecell，SMC)等支持细胞(muralcell)环绕在内皮细胞周围形成完整的新生血管(图2)。

图2

Endothelialcell

(A)Pre-existingbloodvessel

Muralcell

血管生成(A)原有正常血管；(B)内皮细

胞由静止状态转变成具有迁移能力的顶细胞；(C)顶细胞向周围扩增和迁移形成柱状或丝状伪足，，并逐步形成血管腔(lumen)，内皮细胞出芽；(D)血管腔形成；(E)在细胞粘附作用和周细胞、血管平滑肌细胞等支持细胞的作用下形成成熟且稳定的新生血管(图引自[9]并得到许可)

Fig.2SchematicrepresentationoftheangiogenicprocessshowingAngiogenesisstartsfrompre-existingvessels(A),withtheconversionofapreviouslyquiescentendothelialcellintoatip(B).Thelatterformsfilopodiathatprobethesurroundingenvironmentwhichistheninvadedbytheendothelialsprout,wherethetipcellisfollowedbythemigratingcolumn,formedbyproliferatingendothelialcell(C).Duringendothelialsprouting,vacuolesformingwithinstalkcellscoalesceandgiverisetothevascularlumen(D).Uponformationofthenewvessel,thisundergoesstabilizationandmaturation,aprocessmainlymediatedbyintercellularadhesionandmuralcellcoverage(E)(FiguretakenfromRef.9withpermissionfromthepublisher)

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(B)Tipcellformation

Tipcell

Tipcell

(C)Endothelialsproutformation

Migratingcolumn

(D)Lumenformation

(E)Maturation

｜ACTABIOPHYSICASINICA

  本文关键词：肿瘤新生血管及分子靶向治疗新策略，由笔耕文化传播整理发布。