植物多酚通过MAPK信号通路调控肿瘤作用机制研究进展

发布时间：2018-04-10 01:27

本文选题：植物多酚　切入点：丝裂原活化蛋白激酶　出处：《食品科学》2017年07期

【摘要】：肿瘤细胞的生物学过程(增殖、分化、侵袭、迁移)是癌症发生的标志,丝裂原活化蛋白激酶(mitogenactivated protein kinase,MAPK)被证实是调节肿瘤细胞生物学过程的至关重要的信号通路。大量研究表明,天然植物多酚,如茶多酚、白藜芦醇、花青素等对肿瘤细胞有显著的调节作用,植物多酚介导的MAPK通路对肿瘤细胞的调节已经引起国内外学者的广泛兴趣。文章综述了植物多酚通过MAPK信号通路对肿瘤细胞的调控作用,分析了不同多酚对MAPK信号通路的4条途径(p38、ERK-1/2、ERK5、JNK)的响应机制,旨在为明确植物多酚的抗肿瘤活性及分子机制、开发抗肿瘤保健食品或药物提供参考。
[Abstract]:The biological process (proliferation, differentiation, invasion, migration) of tumor cells is a marker of carcinogenesis. Mitogen-activated protein kinases (MAPKs) have been proved to be important signaling pathways for regulating the biological processes of tumor cells.A large number of studies have shown that natural plant polyphenols, such as tea polyphenols, resveratrol, anthocyanin and so on, have a significant regulatory effect on tumor cells. The regulation of MAPK pathway mediated by plant polyphenols on tumor cells has attracted extensive interest from domestic and foreign scholars.In this paper, the regulation of plant polyphenols on tumor cells by MAPK signaling pathway was reviewed. The response mechanism of different polyphenols to four pathways of MAPK signaling pathway p38ERK-1 / 2 ERK5 was analyzed in order to clarify the antitumor activity and molecular mechanism of plant polyphenols.To develop anti-tumor health food or medicine to provide reference.
【作者单位】：西南大学食品科学学院;中华全国供销合作总社昆明食用菌研究所;重庆市特色食品工程技术研究中心;
【基金】：国家自然科学基金面上项目(31471576) 中央高校基本科研业务费专项(XDJK2016E113;XDJK2015D035) “十二五”国家科技支撑计划项目(2013BAD16B01) 重庆市特色食品工程技术研究中心能力提升项目(cstc2014pt-gc8001)
【分类号】：R73-3

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