多发性内分泌腺瘤病1型4例临床分析及文献学习

发布时间：2018-04-10 15:38

本文选题：多发性内分泌腺瘤病1型 + 临床分析　；参考：《浙江大学》2015年硕士论文

【摘要】：目的：探讨多发性内分泌腺瘤病1型(MEN-1)的临床特点和治疗,提高对其认识水平。方法：回顾性分析2013年4月至2014年10月在浙江大学医学院附属邵逸夫医院就诊的4例MEN-1患者的临床资料。结果： 4例患者皆有甲状旁腺腺瘤,3例明确合并胰腺神经内分泌肿瘤,1例高度怀疑合并胰腺神经内分泌肿瘤,1例合并垂体瘤,临床表现因涉及的腺体不同而异。4例患者最后都进行了手术治疗,切除了肿瘤。文献学习：多发性内分泌腺瘤病1型是一种常染色体显性遗传病,可以出现内分泌各个靶器官的肿瘤。其致病基因位于染色体11q13,称为menin基因。MEN-1迄今为止所知道的内分泌肿瘤有20多种,其临床表现各种各样。MEN-1治疗与非MEN-1单发的内分泌腺瘤治疗方式相似,以手术为主,辅以内科治疗、化疗、分子靶向药物等。结论：应重视MEN-1型的诊断线索,早期诊断和早期治疗。MEN-1型的诊断和治疗需要多学科的合作。
[Abstract]:Objective:To investigate the clinical features and treatment of multiple endocrine adenomatosis type 1 (MEN 1) and to improve its understanding.Methods:The clinical data of 4 patients with MEN-1 from April 2013 to October 2014 in run run Shaw Hospital affiliated to Zhejiang University Medical College were retrospectively analyzed.Results:All the 4 patients had parathyroid adenoma. 3 cases were confirmed to have pancreatic neuroendocrine tumor. 1 case was highly suspected to have pancreatic neuroendocrine tumor and 1 case was associated with pituitary adenoma.The clinical manifestations varied according to the glands involved. 4. 4 cases were treated surgically and the tumor was removed.Literature learning:Multiple endocrine adenomatosis type 1 is an autosomal dominant hereditary disease.The pathogenetic gene is located on chromosome 11q13, which is called menin gene. MEN-1 is known to be more than 20 kinds of endocrine tumors so far. Its clinical manifestations are similar to those of non-#en1# single endocrine adenoma.With medical treatment, chemotherapy, molecular targeted drugs and so on.Conclusion:Attention should be paid to the diagnostic cues of MEN-1 type. The diagnosis and treatment of early diagnosis and treatment of MEN-1 require multidisciplinary cooperation.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R736

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