腹腔镜下卵巢囊肿剥除术中垂体后叶素—水囊分离法对卵巢功能的保护作用

发布时间：2018-04-13 01:04

本文选题：垂体后叶素 + 卵巢囊肿　；参考：《宁夏医科大学》2017年硕士论文

【摘要】：目的探讨垂体后叶素-水囊分离法在腹腔镜下卵巢囊肿剥除术中对卵巢功能的保护作用方法1.选取2014年12月~2015年12月就诊于宁夏医科大学总医院妇科行腹腔镜下单侧卵巢囊肿剥除术的患者90例,将患者分为垂体后叶素组(术中局部注射稀释的垂体后叶素)、生理盐水组(术中局部注射生理盐水)和空白对照组(传统方法直接剥除囊肿)各30例。2.应用ELISA法分别检测垂体后叶素组、生理盐水组及空白对照组患者术前、术后1月、3月、6月、12月血清AMH的表达。3.比较垂体后叶素组、生理盐水组、空白对照组三组患者手术时间、手术前后血红蛋白下降量及手术前后不同时间段血清AMH值的变化,使用SPSS 17.0版软件包进行相关统计分析。结果1.垂体后叶素组、生理盐水组与空白对照组比较,三组手术时间分别为(47.03±11.94)、(48.07±13.02)、(53.87±15.82),差异无统计学意义(P0.05);三组手术前后血红蛋白下降量分别为(0.59±0.29)、(0.49±0.24)、(0.65±0.31),差异无统计学意义(P0.05);2.术后1月、术后3月、术后6月三组患者血清AMH值均较术前血清AMH值降低,差异有统计学意义(P0.05);3.术后1月、3月垂体后叶素组、生理盐水组AMH值大于空白对照组,差异有统计学意义(P0.05),术后1月、3月垂体后叶素组血清AMH值与生理盐水组比较,差异无统计学意义(P0.05)。4.术后6月三组患者血清AMH值不同,垂体后叶素组较空白对照组AMH值高,差异有统计学意义(P0.05)。5.三组患者术后12月血清AMH值分别与术前比较,差异均无统计学意义(P0.05)。结论腹腔镜下卵巢囊肿剥除术后卵巢储备功能会降低,使用垂体后叶素水囊分离有保护卵巢功能的作用,具有一定的临床实用价值。
[Abstract]:Objective to investigate the protective effect of pituitrin-water capsule separation on ovarian function during laparoscopic excision of ovarian cysts.From December 2014 to December 2015, 90 patients underwent laparoscopic excision of ovarian cyst in gynecology department, General Hospital of Ningxia Medical University.The patients were divided into three groups: 30 cases in the control group, 30 cases in the control group and 30 cases in the control group, 30 cases in the control group and 30 cases in the group of intraoperative local injection of dilute pituitrin, 30 cases in the normal saline group and 30 cases in the control group respectively.The expression of serum AMH was detected by ELISA method in patients with pituitary hormone group, normal saline group and blank control group before, 1 month, 3 months, 6 months and 12 months after operation.The time of operation, the decrease of hemoglobin before and after operation and the changes of serum AMH in three groups were compared. The statistical analysis was carried out with SPSS 17.0 software package.Result 1.The serum AMH values of the three groups were significantly lower than that of the preoperative serum AMH in 1 month, 3 months and 6 months after operation, and the difference was statistically significant (P 0.05 / 3).The AMH values of the pituitary posterior leaf hormone group and the saline group were significantly higher than those of the blank control group at 1 month and 3 months after operation, and the difference was statistically significant (P 0.05). The serum AMH value of the pituitary posterior leaf hormone group was not significantly higher than that of the normal saline group at 1 month and 3 months after operation.At 6 months after operation, the serum AMH values of the three groups were different, and the AMH value of the pituitary posterior leaf hormone group was higher than that of the blank control group, and the difference was statistically significant (P 0.05).There was no significant difference in serum AMH between the three groups at 12 months after operation compared with that before operation (P 0.05).Conclusion the ovarian reserve function will be decreased after laparoscopic ovarian cystectomy, and the use of hypophyseal posterior leaf water sac can protect the ovarian function, which has certain clinical and practical value.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.33

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