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外泌体的生物特性及其与肿瘤的关系

发布时间:2018-04-13 01:06

  本文选题:外泌体 + 肿瘤微环境 ; 参考:《河北医科大学》2017年硕士论文


【摘要】:外泌体(exosomes)是由双层脂质膜形成的圆形囊泡,其直径在30到100nm之间,呈圆盘状结构。外泌体形成于多泡体,大多数的组织细胞将外泌体分泌于各种体液环境或者细胞培养基之中。在外泌体形成的过程中包裹了来自母体细胞的mi RNA、m RNA、DNA序列及蛋白质等成分,其具有母体细胞的一些功能和特点。外泌体是细胞之间交流的“桥梁”,影响靶细胞的功能。研究发现,外泌体在生理或病理状态(特别是发生肿瘤时)具有不可替代的作用。这篇文章着重介绍了外泌体在肿瘤发生、发展、肿瘤微环境的形成、肿瘤免疫、液体活检及药物传递方面的研究进展,并提出了一些亟待解决的问题。
[Abstract]:Exocrine vesicles are circular vesicles formed by bilayer lipid membranes, whose diameters range from 30 to 100nm, with a disc structure.Exocrine was formed in vesicles, and most of the tissues secreted the exocrine in various humoral environment or cell culture medium.During the process of exocrine formation, the DNA sequences and proteins of the miRNA-mRNAs from the mother cells were encapsulated, which had some functions and characteristics of the mother cells.Exocrine is a bridge between cells, affecting the function of target cells.It has been found that exocrine plays an irreplaceable role in physiological or pathological state, especially in tumorigenesis.This article focuses on the development of exocrine in tumorigenesis, development, the formation of tumor microenvironment, tumor immunity, fluid biopsy and drug delivery, and puts forward some problems to be solved.
【学位授予单位】:河北医科大学
【学位级别】:硕士
【学位授予年份】:2017
【分类号】:R730.2

【参考文献】

相关期刊论文 前1条

1 李思迪;侯信;亓洪昭;赵瑾;原续波;;外泌体:为高效药物投递策略提供天然的内源性纳米载体[J];化学进展;2016年Z2期



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