肺腺癌中Gab2的表达及其预后的分析

发布时间：2018-04-13 03:28

本文选题：肺腺癌 + Gab2　；参考：《广西医科大学》2017年硕士论文

【摘要】：目的:探索在肺腺癌中Gab2高表达与临床病理特征之间的关系,探索Gab2高表达与临床预后之间的关系,旨在探索新的临床预后判断指标,探索新的靶向治疗靶点。方法:取2012年7月3日至2015年2015年1月9日于手术切除的病理标本,肺腺癌组织、癌旁组织病理蜡块,采用免疫组织化学SP法检测检Gab2蛋白的表达,分析其高表达临床病理的关系并作出预后分析。结果:肺腺癌中Gab2的表达情况,癌组织与癌旁高表达卡方检验P值=0.000。肺腺癌中Gab2高表达与TMN分期、脉管癌栓卡方检验P值=0.045、P值=0.011。生存率的单因素Log-rank检验,Gab2高、低表达P值=0.040,脉管癌栓阳、阴性P值=0.001。结论:Gab2在肺腺癌组织中的高表达率为53.3%,高于其在癌旁组织中高表达率6.67%,差异具有统计学意义(P0.05)。在肺腺癌组织中Gab2蛋白的高表达与患者的性别、年龄、分化程度及淋巴结转移无关(P0.05),而与TMN分期、脉管癌栓阳性有关(P0.05)。在肺腺癌患者中,淋巴结转移、TNM分期、Gab2高表达以及脉管癌栓阳性,这些因素都是影响肺腺癌患者预后的重要因素(P0.05)。
[Abstract]:Objective: to explore the relationship between the high expression of Gab2 and the clinicopathological features in lung adenocarcinoma and the relationship between the high expression of Gab2 and the clinical prognosis.Methods: from July 3, 2012 to January 9, 2015, the expression of Gab2 protein was detected by immunohistochemical SP method in lung adenocarcinoma and paracancerous tissues, which were surgically resected from July 3, 2012 to January 9, 2015.The relationship between high expression and clinicopathology was analyzed and the prognosis was analyzed.Results: the expression of Gab2 in lung adenocarcinoma, the high expression of chi-square test (P = 0.000).The high expression of Gab2 and TMN stage were detected in lung adenocarcinoma.In univariate Log-rank test of survival rate, Gab2 was high, low expression P value was 0.040, vessel tumor thrombus positive, negative P value was 0.001.Conclusion the high expression rate of w Gab2 in lung adenocarcinoma is 53.3%, which is higher than that in paracancerous tissues (6.67%). The difference is statistically significant (P 0.05).The high expression of Gab2 protein in lung adenocarcinoma was not related to sex, age, differentiation and lymph node metastasis, but was related to TMN stage and positive vascular tumor thrombus.In patients with lung adenocarcinoma, the high expression of Gab2 in lymph node metastasis and the positive expression of vascular tumor thrombus were all important factors affecting the prognosis of lung adenocarcinoma patients (P 0.05).
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2

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