高分化和非高分化肝癌在钆塞酸二钠多模态MRI中的对照研究

发布时间：2018-04-13 14:01

本文选题：高分化肝癌 + 钆塞酸二钠　；参考：《实用医学杂志》2017年24期

【摘要】：目的比较高分化肝癌(WHCC)和非高分化肝癌在钆塞酸二钠(GD-EOB-DTPA)多模态MRI成像中的差异,总结WHCC的MRI影像特点。方法回顾性收集57例经手术病理证实为肝细胞癌(HCC)患者的临床和影像资料,所有患者行肝脏平扫(T1WI和T2WI)、弥散加权成像(DWI)、表观弥散系数(ADC)图、GD-EOB-DTPA增强多期扫描。研究分为WHCC(高分化HCC)及非WHCC(包括中分化和低分化HCC)。统计和分析WHCC与非WHCC在T1WI信号、T2WI信号、DWI信号、ADC图信号、强化模式、肝胆管期信号上的差异。结果将WHCC与非WHCC的影像特征进行对比发现:T1WI信号、肝胆管期信号、ADC图信号、强化模式差异均有统计学意义(P0.05)。多因素Logistic回归分析显示,T1WI信号是预测WHCC的独立影响因素(OR=0.071,P=0.001),进一步比较T1WI的高、等、低3组信号,发现T1WI的高信号对预测WHCC的发生率高于T1WI的等信号和低信号,差异具有统计学意义(P=0.002)。结论 GD-EOB-DTPA多模态成像有利于预测WHCC,其中T1WI信号是独立影响因素,且T1WI的高信号是主要征象,能更好地预测WHCC。
[Abstract]:Objective to compare the difference between well-differentiated liver cancer (WHCC) and non-differentiated liver cancer (MRI) in multimodal MRI imaging of GD-EOB-DTPA, and to summarize the characteristics of WHCC MRI images.Methods the clinical and imaging data of 57 patients with hepatocellular carcinoma (HCC) proved by surgery and pathology were retrospectively collected. All the patients were examined with plain scan T1WI and T2WIWI, DWI, DWI, and GD-EOB-DTPA enhanced multiphase scanning.The study was divided into two groups: WHCC (highly differentiated HCC) and non-WHCC (moderately differentiated and poorly differentiated HCC).The difference between WHCC and non-DWI in T1WI signal T _ 2WI signal, enhancement mode, and signal intensity in hepatic bile duct phase was analyzed and statistically analyzed.Results comparing the imaging features of WHCC with that of non-, we found that there were significant differences in the signal intensity of 1: T1WI, the signal of hepatobiliary phase and the enhancement mode (P 0.05).Multivariate Logistic regression analysis showed that T1WI signal was an independent influencing factor in predicting WHCC. Compared with the high, equal and low signal of T1WI, it was found that the incidence of high signal of T1WI in predicting WHCC was higher than that of T1WI, and the incidence of T1WI was higher than that of T1WI.The difference was statistically significant.Conclusion GD-EOB-DTPA multimodal imaging is helpful to predict T1WI, in which T1WI signal is an independent factor, and the high signal of T1WI is the main sign, so it can better predict WHCC.
【作者单位】：南方医科大学南方医院影像中心;
【基金】：国家重点研发计划基金项目(编号:2016YFC0107104)
【分类号】：R445.2;R735.7

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