咖啡酸片治疗肿瘤化疗所致血小板减少症的临床观察

发布时间：2018-04-13 14:26

  本文选题：咖啡酸片 + 肿瘤化疗　； 参考：《中国肿瘤临床》2017年17期

【摘要】：目的:观察咖啡酸片治疗肿瘤化疗所致血小板减少症(chemotherapy induced thrombocytopenia,CIT)的临床疗效及安全性。方法:采用自身对照的方法,选取上海交通大学医学院附属瑞金医院等11家三级甲等医院2016年1月22日至2017年1月10日收治的60例肿瘤化疗所致CIT患者。给予咖啡酸片/模拟剂治疗,均为3片/次,3次/d。第1个化疗周期(阴性对照期)于化疗开始第1 d给予咖啡酸片模拟剂;第2、3个化疗周期(药物治疗期)需要接受与第1个化疗周期相同方案及剂量的化疗,分别于化疗开始第1 d给予咖啡酸片。结果:药物治疗期最低血小板(platelet,PLT)的升高值显著高于阴性对照期(P0.001);药物治疗期化疗后,PLT恢复后最高值显著高于阴性对照期(P0.001);药物治疗期PLT50×10~9/L的持续天数与阴性对照期无显著性差异,但有缩短趋势(P0.05);药物治疗期化疗后PLT恢复至≥75×10~9/L和≥100×10~9/L,所需的天数较阴性对照期均明显减少(P0.001);试验期间无患者行PLT输注。结论:咖啡酸片用于肿瘤化疗所致CIT患者,疗效确切,不良反应较少,具有广泛的临床应用前景。
[Abstract]:Objective: to observe the clinical efficacy and safety of caffeic acid tablets in the treatment of induced thrombocytopenia caused by tumor chemotherapy-induced thrombocytopenia.Methods: by using self-control method, 60 patients with CIT caused by tumor chemotherapy were selected from 11 Grade 3A hospitals such as Ruijin Hospital, Shanghai Jiaotong University Medical College from January 22, 2016 to January 10, 2017.Caffeic acid tablets / analogue were treated with 3 tablets / 3 times / d.The first chemotherapy cycle (negative control period) was treated with caffeic acid tablet mimics on the first day of chemotherapy, and the 2nd and 3rd chemotherapy cycles (drug treatment period) required the same regimen and dose of chemotherapy as the first chemotherapy cycle.Caffeic acid tablets were given on the first day of chemotherapy.Results: the elevated value of PLT was significantly higher than that of the negative control group (P 0.001), the highest value after chemotherapy was significantly higher than that in the negative control group (P 0.001), and the duration of PLT50 脳 10 9 / L in the drug treatment phase was not significantly different from that in the negative control group.However, there was a tendency to shorten P0. 05%, PLT recovered to 鈮，

本文编号：1744932