面部基底细胞癌临床病理分析及安全切缘的关系

发布时间：2018-04-13 16:34

本文选题：基底细胞肿瘤 + 病理分型　；参考：《临床与实验病理学杂志》2017年01期

【摘要】：目的探讨面部不同分型基底细胞癌(basal cell carcinoma,BCC)的临床病理特征、切缘情况及影响因素。方法回顾性分析300例BCC的临床病理特征及不同手术切缘下的术中冷冻切缘情况及影响因素,并复习相关文献。利用Logistic多元回归模型分析BCC病理分型、手术切缘、肿瘤直径及发生位置等对首次术中冷冻切缘阳性率的影响。结果 Logistic多元回归分析显示病理分型是首次术中冷冻切缘阳性率的主要危险因素;浸润型(OR=4.463,95%CI=1.919~10.380,P0.05)和硬斑病样型(OR=5.018,95%CI=2.025~16.623,P0.05)与结节型BCC相比,发生切缘阳性的风险较高;在不同切缘下,结节型、浅表型BCC切缘阳性率差异无统计学意义(P0.05)。结论病理分型是影响BCC手术切缘安全的独立因素;面部结节型、浅表型BCC,采用3 mm手术切缘可达理想手术效果。
[Abstract]:Objective to investigate the clinicopathological features, incisal margin and influencing factors of basal cell carcinoma (BCC) in different facial classification.Methods the clinicopathological features of 300 cases of BCC were analyzed retrospectively.Logistic multivariate regression model was used to analyze the effects of pathological classification, surgical margin, tumor diameter and location of tumor on the positive rate of frozen margin in the first operation.Results Logistic multivariate regression analysis showed that pathological classification was the main risk factor for the positive rate of freeze-cut margin in the first operation, and the invasive type ORA 4.463 + 95 CI1.919 ~ 10.380 (P0.05) and hard spot disease type OR5.018 ~ 95CII 2.025252516.623P0.05) had a higher risk of positive margin than that of nodular BCC, and the risk of positive margin was higher than that of nodular BCC, and the risk of positive margin was higher than that of nodular BCC.There was no significant difference in the positive rate of BCC margin between nodular type and superficial type (P 0.05).Conclusion pathological classification is an independent factor affecting the safety of BCC surgical margin, and the facial nodular and superficial BCCs can achieve satisfactory results with 3 mm surgical margin.
【作者单位】：安徽医科大学附属省立医院整形外科;安徽医科大学附属省立医院病理科;
【分类号】：R739.5

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