多形性胶质母细胞瘤112例临床分析

发布时间：2018-04-14 21:36

本文选题：多形性胶质母细胞瘤 + 替莫唑胺　；参考：《广东医学》2017年01期

【摘要】：目的探讨多形性胶质母细胞瘤(GBM)手术后联合不同辅助治疗手段对患者预后的影响。方法对112例首诊GBM患者的临床资料进行随访及回顾性分析。采用Kaplan-Meier法计算生存率并绘制生存曲线,用log-rank检验方法进行单因素分析,对影响生存时间的多因素进行COX回归分析。结果 112例患者纳入分析,随访结束存活18例,随访期间死亡94例,平均生存时间(14.7±1.69)个月。手术全切、IDH1突变阳性、术后2~4周内开始放疗、Stupp方案后长周期维持替莫唑胺影响患者的总生存时间。COX回顾分析显示患者手术全切(P=0.003)、术后2~4周开始放疗(P=0.000)是影响生存时间的独立因素。挽救性治疗手段对生存时间的影响,差异无统计学意义(P0.05)。结论手术全切及术后早期开始放疗能延长GBM患者生存期,以IDH1/2基因为代表的分子检测能很好地判断高级别胶质瘤的生存预后。
[Abstract]:Objective to investigate the effect of different adjuvant therapy combined with GBM on the prognosis of patients with glioblastoma pleomorphic.Methods the clinical data of 112 patients with GBM were analyzed retrospectively.The survival rate was calculated by Kaplan-Meier method and the survival curve was drawn. The single factor analysis was carried out by log-rank test, and the multiple factors affecting survival time were analyzed by COX regression analysis.Results of 112 patients, 18 survived and 94 died during the follow-up, with an average survival time of 14.7 卤1.69 months.IDH1 mutation was positive in total excision.The overall survival time of patients was affected by the long-term maintenance of temozolidomide within 2 to 4 weeks after radiotherapy. Cox retrospective analysis showed that total resection of P0. 003 and radiotherapy of P0. 000 at 24 weeks after operation were independent factors affecting survival time.There was no significant difference in the effect of salvage therapy on survival time (P 0.05).Conclusion Total resection and early postoperative radiotherapy can prolong the survival time of GBM patients. The molecular detection of IDH1/2 gene can be used to evaluate the survival and prognosis of high grade gliomas.
【作者单位】：广东三九脑科医院肿瘤综合治疗中心;中山大学肿瘤防治中心神经外科/神经肿瘤科华南肿瘤学国家重点实验室癌症医学协同创新中心;
【基金】：广东省建设中医药强省立项资助科研课题(编号:20151169)
【分类号】：R739.41

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