化疗联合中药治疗在结直肠癌术后的临床效果观察

发布时间：2018-04-14 22:02

本文选题：结直肠癌 + 化疗　；参考：《山西医科大学》2015年硕士论文

【摘要】：目的:观察结直肠癌术后使用FOLFOX6方案化疗期间联合中药治疗的临床疗效及不良反应。方法:将60例结直肠癌术后的患者随机分为2组,中药组(30例)化疗期间联合中药治疗,对照组(30例)单纯化疗。化疗方案:FOLFOX6方案为:奥沙利铂注射液以每平方米85mg的量第一天静脉滴注,并且于2小时内输入完毕,亚叶酸钙注射液以每平方米400 mg的量第一天静脉滴注,并且于2小时内输入完毕,氟尿嘧啶注射液每平方米400 mg于第一天静脉推注,氟尿嘧啶注射液每平方米1200mg持续静脉滴注两天(总量每平方米2400mg输注46-48h)于第一天开始,每2周重复1次,采用x2检验及t检验,对两组间中医证候疗效、中医症状积分、外周血细胞计数、消化道反应、肝功能、神经毒性反应和T细胞亚群进行统计学分析。结果:疗程结束后中药组与对照组中医证候疗效有效率分别为70.00%、26.67%(P0.05),对应中医症状积分分别为8.36±3.81、15.40±4.90(P0.05)。两组患者化疗后实验室检查的比较:中药组在减少肝功能损伤的效果明显优于对照组,其差异性有统计学意义(P0.05),而白细胞的变化无统计学意义,主要消化道反应和神经毒性反应相比差异有统计学意义(P0.05),两组CD4+(%)和CD8+(%)比较分别为:43.40±5.09 vs 35.09±5.28,30.20±5.63vs 34.13±5.90,中药组CD4+(%)较对照组明显升高,而CD8+(%)明显减低(均P0.05)。结论:结直肠癌术后化疗时配合中药口服治疗,可以减少结直肠癌患者术后的并发症改善其生存质量,还可以提高患者的免疫力,效果显著,值得在今后的临床工作中广泛使用。
[Abstract]:Objective: to observe the clinical effect and adverse reaction of FOLFOX6 regimen combined with Chinese medicine after colorectal cancer operation.Methods: sixty patients with colorectal cancer after operation were randomly divided into two groups: the Chinese medicine group (n = 30) and the control group (n = 30).Chemotherapy regimen: FOLFOX6: oxaliplatin injection was given intravenously per square meter of 85mg on the first day, and was infused within 2 hours, and calcium folate injection was given intravenously at 400 mg per square meter on the first day.At the end of the infusion within 2 hours, fluorouracil injection (400mg per square meter) was injected intravenously on the first day, and fluorouracil injection per square meter 1200mg continued for two days (46-48 hours per square meter of 2400mg) from the first day.Every 2 weeks, the effect of TCM syndrome, TCM symptom score, peripheral blood cell count, digestive tract reaction, liver function, neurotoxic reaction and T cell subgroup were statistically analyzed by x2 test and t test.Results: after the course of treatment, the effective rates of TCM syndromes in the TCM group and the control group were 70.00,26.67 and 8.36 卤3.81 卤15.40 卤4.90, respectively, and the corresponding scores of TCM symptoms were 8.36 卤3.81 and 15.40 卤4.90, respectively.Comparison of laboratory examination after chemotherapy in two groups: the effect of traditional Chinese medicine group on reducing liver function injury was significantly better than that of control group, the difference was statistically significant (P 0.05), but the change of white blood cell was not statistically significant.There was significant difference in the main digestive tract reaction and neurotoxic reaction between the two groups (P 0.05). The ratio of CD4 and CD8 were 43.40 卤5.09 vs 35.09 卤5.2830.20 卤34.13 卤5.90, respectively. The CD4 in the Chinese medicine group was significantly higher than that in the control group, but CD8 was significantly decreased (P 0.05).Conclusion: the postoperative chemotherapy combined with oral Chinese medicine can reduce the postoperative complications and improve the quality of life of patients with colorectal cancer, and it can also improve the immunity of patients with colorectal cancer.It is worthy to be widely used in clinical work in the future.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735.34

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