TE和TC方案在老年乳腺癌新辅助化疗中的临床研究

发布时间：2018-04-16 01:10

本文选题：老年乳腺癌 + 新辅助化疗　；参考：《青海大学》2017年硕士论文

【摘要】：目的:探讨TE(多西他赛+表柔比星)和TC(多西他赛+环磷酰胺)方案在老年乳腺癌患者新辅助化疗中的疗效及安全性,为选择最佳方案提供临床依据。方法:收集60例满足入组标准的老年乳腺癌患者资料。随机分为TE组、TC组两组。分别予以TE或TC方案新辅助化疗,每3周重复一次。每2周期化疗后复查患者病情变化,同时记录不良反应的发生。新辅助化疗结束后比较两组的近期疗效、手术治疗(R0切除)率及化疗毒副作用,对数据行统计分析。结果:TE组与TC组临床有效率(CR+PR)分别为81.25%、75.00%,无显著性差异(P0.05)。其中78.3%的患者在新辅助化疗结束后完成了手术治疗。TE组行手术(R0切除)治疗患者占84.38%(27/32),TC组占71.43%(20/28),差异无统计学意义(P0.05)。化疗毒副作用方面,TE与TC组相比较,心脏毒性发生率分别为28.12%(9/32)及14.29%(4/28),差异无统计学意义(P0.05)。贫血方面差异亦无统计学意义(P0.05)。两组在胃肠道反应、口腔溃疡、中性粒细胞减低方面,差异具有统计学意义(P0.05),并且在Ⅲ度以上不良反应的差异主要体现在胃肠道反应方面(P0.05)。结论:TC方案疗效与TE方案相当,但相对TE方案而言,TC方案的毒副作用较轻,对于老年乳腺癌患者耐受性良好,值得临床推广。
[Abstract]:Objective: to investigate the efficacy and safety of TC- and TE- (docetaxepirubicin) regimen in neoadjuvant chemotherapy in elderly patients with breast cancer, and to provide clinical basis for selecting the best regimen.Methods: 60 cases of elderly breast cancer patients who met the standard of admission were collected.They were randomly divided into te group and TC group.Neoadjuvant chemotherapy with te or TC regimen was given every 3 weeks.After 2 cycles of chemotherapy, the changes of the patient's condition and the occurrence of adverse reactions were recorded.After neoadjuvant chemotherapy, the short-term curative effect, the rate of surgical treatment and the side effects of chemotherapy were compared between the two groups. The data were statistically analyzed.Results the clinical effective rates of the two groups were 81.25% and 75.00, respectively. There was no significant difference between the two groups (P 0.05).After neoadjuvant chemotherapy, 78.3% of the patients completed the operation. Te group was treated with R0.) the proportion of the patients treated was 84.38%. The proportion of the patients in the TC group was 71.43%. There was no significant difference between the two groups (P 0.05).Compared with TC group, the incidence of cardiac toxicity was 28.1212 / 32 in te group and 14.29 / 28 / 28 in TC group. The difference was not statistically significant (P 0.05).There was no significant difference in anemia (P 0.05).The difference between the two groups in gastrointestinal reaction, oral ulcer and neutropenia was statistically significant (P 0.05).Conclusion compared with the te regimen, the effect of the fraction of TC regimen is similar to that of the te regimen, but the toxicity and side effects of the regimens are relatively mild, which is worthy of clinical application for the elderly patients with breast cancer.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9

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