PD-L1在术后食管鳞癌中的表达及其预后价值

发布时间：2018-04-16 17:55

本文选题：PD-L1 + 食管癌　；参考：《浙江大学》2017年硕士论文

【摘要】：目的:检测程序性死亡分子配体-1(programmed death ligand-1,PD-L1)在术后食管鳞癌中的表达,评估其在指导食管鳞癌临床治疗中的预后价值,探索其是否能够指导食管鳞癌免疫治疗的临床应用。方法:采用单中心回顾性研究方法,选择2014年6月1日至2016年6月1日于浙江大学医学院附属医院行食管癌根治术的患者,筛选出术后有随访及继续治疗的45例食管鳞癌患者。对45例患者术后的食管癌病理标本进行切片,采用免疫组化的方法检测病理切片中PD-L1的表达。根据免疫组化的结果将病人分为PD-L1阳性组和阴性组,采用卡方检验评估PD-L1的表达和患者临床特征及病理因素的关系,采用对数秩检验确定不同临床病理特征患者的生存差异。结果:PD-L1表达阳性的患者皆为男性,有吸烟史、饮酒史,有淋巴结转移。但经统计分析,PD-L1的表达与年龄、性别、吸烟史、饮酒史、大体类型、淋巴结转移、分化程度、病理分期差异无统计学意义,P值分别为0.517,0.696,0.286,0.503,0.641,0.206,0.401,0.788。PD-L1表达阳性组的DFS同PD-L1表达阴性组的DFS差异无统计学意义,P值为0.551。PD-L1表达阳性组的OS同PD-L1表达阴性组的OS差异无统计学意义,P值为0.854。结论:PD-L1在术后食管鳞癌中的表达与患者的性别、年龄、吸烟史、饮酒史、大体类型、分化程度、淋巴结转移、病理分期无关。不管是单因素还是多因素分析,PD-L1的表达与总生存期、无病生存期都无关。
[Abstract]:Objective: to detect the expression of programmed death molecular ligand (-1C) -programmed death ligand PD-L1) in postoperative esophageal squamous cell carcinoma, to evaluate its prognostic value in guiding the clinical treatment of esophageal squamous cell carcinoma, and to explore whether it can guide the clinical application of immunotherapy for esophageal squamous cell carcinoma.Methods: a single center retrospective study was used to select 45 patients with esophageal squamous cell carcinoma who underwent radical esophagectomy from June 1, 2014 to June 1, 2016 in the affiliated Hospital of Zhejiang University Medical College.The expression of PD-L1 in 45 patients with esophageal carcinoma was detected by immunohistochemical method.According to the results of immunohistochemistry, the patients were divided into PD-L1 positive group and negative group. Chi-square test was used to evaluate the relationship between the expression of PD-L1 and clinical features and pathological factors, and logarithmic rank test was used to determine the survival difference of patients with different clinicopathological characteristics.Results all of the patients with positive expression of w-PD-L1 were male. They had a history of smoking, drinking, and lymph node metastasis.But the expression of PD-L1 was correlated with age, sex, smoking history, drinking history, gross type, lymph node metastasis and differentiation.There was no significant difference in pathological staging (P = 0.517) 0.696U 0.286U 0.503n 0.641C 0.206U 0.401U 0.788.There was no significant difference in DFS between DFS and PD-L1 negative group. There was no significant difference in P value between OS and PD-L1 expression group (P = 0.854).Conclusion the expression of the weight PD-L1 in postoperative esophageal squamous cell carcinoma is not related to sex, age, smoking history, drinking history, gross type, differentiation degree, lymph node metastasis and pathological stage.Neither univariate nor multivariate analysis showed that the expression of PD-L1 was not related to total survival and disease-free survival.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.1

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