多形性胶质母细胞瘤的临床综合治疗进展

发布时间：2018-04-16 23:15

本文选题：多形性胶质母细胞瘤 + 手术　；参考：《河北医科大学》2017年硕士论文

【摘要】：目的:总结多形性胶质母细胞瘤的临床综合治疗进展。内容:多形性胶质母细胞瘤是最常见的颅内原发恶性脑瘤,恶性程度极高。即使应用目前指南规定的标准化治疗,患者仍然面临肿瘤复发直至死亡。查阅近几年国内外的期刊杂志及治疗指南,归纳了多形性胶质母细胞瘤临床特点,以及罗列了其治疗过程中手术治疗、放射治疗、化学治疗,靶向治疗及免疫治疗的现状及其新方向,并分析了包括疫苗、过继T细胞疗法、免疫检查点封锁、单克隆抗体、细胞因子治疗以及免疫调节治疗在内的免疫治疗的安全性及有效性。方法及结果:利用网络资源查找近几年国内外的期刊杂志及治疗指南,仔细研读、翻译。结论:多形性胶质母细胞瘤在标准化治疗的同时仍应该不断提升手术方式方法,不断增加治疗的新手段及新方式。
[Abstract]:Objective: to summarize the progress of clinical comprehensive treatment of pleomorphic glioblastoma.Content: glioblastoma pleomorphic is the most common intracranial primary malignant brain tumor with a high degree of malignancy.Even with standardized treatment as currently prescribed in the guidelines, patients still face tumor recurrence and death.The clinical features of glioblastoma pleomorphism were summarized by consulting the journals and treatment guidelines at home and abroad in recent years, and the surgical treatment, radiation therapy and chemotherapy during the course of treatment were listed.The current situation and new direction of targeted therapy and immunotherapy were analyzed, including vaccine, adoptive T cell therapy, immune checkpoint blockade, monoclonal antibody,The safety and efficacy of immunotherapy including cytokine therapy and immunomodulation therapy.Methods and results: using the network resources to look up the domestic and foreign journals and treatment guidelines carefully read and translate.Conclusion: in addition to standardized treatment of glioblastoma pleomorphic glioblastoma, surgical methods should be continuously upgraded, and new methods of treatment should be continuously increased.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R739.41

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