肝癌边缘假包膜与病理组织学分级相关性研究

发布时间：2018-04-17 18:27

  本文选题：原发性肝癌 + 假包膜　； 参考：《广西医科大学》2017年硕士论文

【摘要】：目的:研究肝细胞癌的边缘假包膜特点对其病理组织学分级的诊断价值。方法:分析自2013年6月至2014年12月在广西医科大学第一附属医院经手术或活检病理证实为肝细胞癌,且病理诊断中包含肿瘤病理组织学分级的564例病人的影像资料,其中男性484例,女性80例,年龄范围18-80岁,平均年龄49岁。通过观察肝细胞癌CT、MRI出现边缘假包膜的影像表现,包括边缘假包膜有无、是否完整以及假包膜在多期扫描图像上强化最明显时相等多项指标,分析肝癌假包膜与其病理组织学分型的关系。统计学的分析以及处理采用SPSS22.0统计软件。结果:本研究CT和MRI检出肝癌边缘假包膜的差异有统计学意义(P0.05);小肝癌(直径≤3cm),结节型肝癌(3cm,≤5cm),巨块型肝癌(5cm)组之间病灶边缘假包膜的有无、是否完整的差异有统计学意义(P0.05);肝癌的病理分化Ⅰ型(高分化肝癌、高-中分化肝癌)、Ⅱ型(中分化肝癌、中-低分化肝癌)、Ⅲ型(低、低-未分化、未分化肝癌)组之间,病灶边缘假包膜完整率的差异有统计学意义(P0.05);不同病理分化程度的肝癌假包膜强化最明显的时相,在动脉期与门脉期强化最明显、动脉期与平衡期强化最明显的分布差异有统计学意义(P0.05)。结论:肝癌CT和MRI假包膜检出率比较,MRI优于CT;肝癌病灶越大,边缘假包膜检出率越高,且假包膜表现为越不完整;假包膜完整率越低,肝癌病理分化程度越低;假包膜在动脉期强化最明显,提示肝癌病理分化程度越低。
[Abstract]:Objective: to study the diagnostic value of marginal pseudocapsule characteristics in hepatocellular carcinoma (HCC).Methods: from June 2013 to December 2014, the imaging data of 564 patients with hepatocellular carcinoma confirmed by operation or biopsy pathology in the first affiliated Hospital of Guangxi Medical University were analyzed.There were 484 males and 80 females, aged 18-80 years, with an average age of 49 years.The imaging features of marginal pseudocapsule in CT MRI of hepatocellular carcinoma (HCC) were observed, including whether or not the marginal pseudocapsule was present, whether the pseudocapsule was intact, and when the pseudocapsule was enhanced most obviously on the multiphase scanning images.To analyze the relationship between pseudocapsule and histopathological classification of liver cancer.Statistical analysis and processing using SPSS22.0 statistical software.Results: in this study, the difference between CT and MRI in detecting the marginal pseudocapsule of HCC was statistically significant (P 0.05), and in the small hepatocellular carcinoma (diameter 鈮，

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