动态增强磁共振对前列腺癌的诊断价值的系统评价和meta分析

发布时间：2018-04-18 23:00

本文选题：诊断成像 + 磁共振成像　；参考：《宁夏医科大学》2017年硕士论文

【摘要】：目的通过系统评价和Meta分析是评估动态增强磁共振成像(DCE)对前列腺癌(PCa)患者的临床诊断价值和探讨此检查方法的优势和缺陷。方法系统检索Pubmed,Embase,Cochrane Library,Cochrane Central Register of Controlled Trials(CENTRAL)数据库中已发表的相关英文文献,检索时间为2000年一月至2016年9月。通过纳入排除标准对文献进行筛选,使用QUSDAS-2标准对纳入文献进行文献质量评价,利用RevMan 5和SAS 9.3软件进行数据分析。使用以病人人数计算和病灶部位为单位,分别计算其敏感性、特异性、加权SROC曲线下面积(AUC)评价DCE的诊断效能,同时也录入文献中其他相关检查方法数据,例如DWI、MRS、T2WI检查。利用直接和间接比较对DCE和其他方法进行比较其诊断效能。结果最终共纳入26篇文献,整个腺体试验组合并敏感度为0.55(95%CI 0.42-0.67),合并特异度为0.89(95%CI 0.84-0.92)。外周带合并敏感度0.69(95%CI 0.40-0.88)及合并特异度0.87(95%CI 0.73-0.95)。对比DWI,在整个腺体试验组及外周带试验组上,DCE敏感度要差于DWI。结论DCE作为一个辅助技术,有相对较好的特异度可以区分正常组织和癌灶的功能。
[Abstract]:Objective to evaluate the clinical diagnostic value of dynamic enhanced magnetic resonance imaging (DCE) in patients with prostate cancer by systematic evaluation and Meta analysis.Methods the relevant English literature published in the Pubmedus Embase Central Register of Controlled Trialsbus Register database was searched from January 2000 to September 2016.Through the inclusion of exclusion criteria to screen the literature, using the QUSDAS-2 standard to evaluate the quality of the included literature, using RevMan 5 and SAS 9.3 software for data analysis.The sensitivity, specificity, and area under weighted SROC curve were calculated to evaluate the diagnostic efficacy of DCE, and other data of other relevant examination methods, such as DWI MRS T 2WI, were also inputted in the literature.Direct and indirect comparisons were used to compare the diagnostic effectiveness of DCE and other methods.Results A total of 26 articles were included. The combined sensitivity and specificity of the whole glandular trial group were 0.55(95%CI 0.42-0.67 and 0.89(95%CI 0.84-0.92g respectively.Peripheral band combined sensitivity 0.69(95%CI 0.40-0.88) and combined specificity 0.87(95%CI 0.73-0.95g.Compared with DWI, the sensitivity of DCE in the whole glandular trial group and the peripheral zone test group was lower than that in the DWI group.Conclusion as an auxiliary technique, DCE has relatively good specificity in differentiating the function of normal tissues from cancer foci.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R737.25

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