P16及HPV16在鼻腔鼻窦鳞状细胞癌中的关系研究

发布时间：2018-04-19 01:10

本文选题：P + HPV　；参考：《临床耳鼻咽喉头颈外科杂志》2017年24期

【摘要】：目的:探讨鼻腔鼻窦鳞状细胞癌中P16蛋白表达和HPV16感染情况与肿瘤临床特征、预后的关系以及二者的相关性。方法:收集经病理科诊断为鼻腔鼻窦鳞状细胞癌的组织标本55例,并以鼻内翻性乳头状瘤20例、鼻息肉组织20例作为对照组,应用免疫组织化学法检测P16蛋白表达和HPV16感染情况。结果:P16及HPV16在鼻腔鼻窦鳞状细胞癌组织及内翻性乳头状瘤组织中的阳性率均显著高于鼻息肉组,差异有统计学意义(P0.05或0.01)。P16表达与肿瘤病理分级、临床分期具有相关性(P0.05),而与性别、年龄、吸烟、肿瘤原发部位无关(P0.05);HPV16感染与肿瘤病理分级、临床分期、性别、年龄、吸烟及肿瘤原发部位无关(P0.05)。在鼻腔鼻窦鳞状细胞癌组织中,P16表达与HPV16感染呈显著正相关(r=0.483,P0.01);KaplanMeier生存分析显示,P16、HPV16阳性组的平均生存期和中位生存期均高于同指标阴性组,差异均有统计学意义(P0.05)。结论:P16蛋白表达失控、HPV16感染与鼻腔鼻窦鳞状细胞癌的发生、进展密切相关,并且二者具有一定相关性,P16/HPV16阳性提示预后趋势更好。
[Abstract]:Objective: to investigate the relationship between the expression of P16 protein and HPV16 infection in squamous cell carcinoma of nasal cavity and paranasal sinuses and the relationship between the expression of P16 protein and the clinical features, prognosis and the correlation between P16 protein expression and HPV16 infection.Methods: 55 cases of squamous cell carcinoma of nasal cavity and sinuses were collected, 20 cases of nasal inverted papilloma and 20 cases of nasal polyp as control group.Immunohistochemical method was used to detect the expression of P16 protein and HPV16 infection.Results the positive rates of P16 and HPV16 in squamous cell carcinoma of nasal cavity and nasal sinuses and inverted papilloma were significantly higher than those in nasal polyps (P0.05 or 0.01).P16 expression and pathological grade).The clinical stage was correlated with P0.05, but not with sex, age, smoking, primary location of tumor, infection of HPV16 and pathological grade of tumor, clinical stage, sex, age, smoking and primary location of tumor.There was a significant positive correlation between the expression of P16 and HPV16 infection in the squamous cell carcinoma of nasal cavity and paranasal sinuses. Kaplan Meier survival analysis showed that the mean survival time and median survival time of P16 + HPV16 positive group were higher than those of the same negative group, and the difference was statistically significant (P0.05).Conclusion the infection of HPV16 is closely related to the occurrence and progression of squamous cell carcinoma of nasal cavity and paranasal sinuses, and the positive rate of P16 / HPV16 indicates a better prognosis.
【作者单位】：中国医科大学附属第一医院耳鼻咽喉科;
【分类号】：R739.62

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