血清Cyfra21-1、SCCA和TK1基线水平与肺癌预后关系的巢式病例对照研究

发布时间：2018-04-19 03:31

  本文选题：肺癌 + 鳞状细胞癌抗原　； 参考：《中国免疫学杂志》2017年05期

【摘要】：目的:探讨Cyfra21-1、SCCA和TK1水平与肺癌预后关系。方法:采用巢式病例对照研究方法,以2010年1月至2013年1月首诊无远处转移的721肺癌患者为基线队列,以随访期间(2年)死亡或脑(或多处)转移的364例患者为病例组,其他357例纳入对照组。检测两组血清Cyfra21-1、SCCA和TK1水平,分析三者与肺癌预后关系。结果:两组间体重指数、吸烟情况、病理类型、临床分期、淋巴转移、合并慢性疾病等,差异有统计学意义(P0.05),两组胸腔积液、综合治疗情况等,差异无统计学意义(P0.05);两组Cyfra21-1、SCCA和TK1基线水平,差异有统计学意义(P0.05);两组间Cyfra21-1、SCCA、SCCA和TK1的分布情况,差异有统计学意义(P0.05);不同临床分期肺癌患者Cyfra21-1基线水平比较,差异有统计学意义(P0.05),SCCA和TK1差异无统计学意义(P0.05);不同病理类型肺癌患者Cyfra21-1、SCCA基线水平比较,差异有统计学意义(P0.05),TK1差异无统计学意义(P0.05)。多因素Logistic分析显示Cyfra21-1、SCCA和TK1水平肺癌预后不良的OR值(95%CI)分别为7.235(1.674~14.613)、5.009(0.973~10.778)、5.816(0.879~16.235)。结论:Cyfra21-1基线水平与肺癌预后有关,可增加预后不良的危险性,SCCA和TK1水平变化与肺癌预后无关。
[Abstract]:Objective: to investigate the relationship between the levels of SCCA and TK1 in Cyfra21-1 and the prognosis of lung cancer.Methods: a nested case-control study was conducted with a baseline cohort of 721 lung cancer patients with no distant metastasis from January 2010 to January 2013, and 364 patients who died or had brain (or multiple) metastases during the follow-up period (2 years).Other 357 cases were included in the control group.The serum levels of Cyfra21-1 and TK1 were measured, and the relationship between them and the prognosis of lung cancer was analyzed.Results: there were significant differences in body mass index (BMI), smoking status, pathological type, clinical stage, lymphatic metastasis and chronic disease between the two groups (P 0.05).There was no significant difference between the two groups (P 0.05); the baseline level of Cyfra21-1 and TK1 was statistically significant (P 0.05); the distribution of SCCA and TK1 in the two groups was statistically significant (P 0.05); the baseline level of Cyfra21-1 in patients with different clinical stages of lung cancer was higher than that in the control group.There was no significant difference between SCCA and TK1 in patients with different pathological types of lung cancer (P 0.05), but there was no significant difference in baseline level of Cyfra21-1 and TK1 in patients with different pathological types of lung cancer (P 0.05).Multivariate Logistic analysis showed that the OR value of poor prognosis of lung cancer in Cyfra21-1SCCA and TK1 was 7.235 ~ 1.674 ~ 14.613 ~ 5.009 ~ 0.973 ~ (10.778) and 5.816 ~ (0.879) ~ (16.235) respectively.Conclusion the baseline level of Cyfra21-1 is related to the prognosis of lung cancer, and the risk of poor prognosis is increased. The changes of SCCA and TK1 levels are not related to the prognosis of lung cancer.
【作者单位】： 华北理工大学附属医院呼吸科;滦南县医院影像科;
【基金】：河北省卫生厅医学课题(20160731)资助项目
【分类号】：R734.2
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本文编号：1771412