外周血中性粒细胞与淋巴细胞比值评估小细胞肺癌患者预后的价值

发布时间：2018-04-19 03:20

本文选题：癌 + 小细胞　；参考：《中华疾病控制杂志》2017年08期

【摘要】：目的探讨治疗前外周血中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)与小细胞肺癌患者预后的关系。方法回顾性分析2013年1月~2015年3月安徽医科大学第一附属医院病理诊断明确的50例小细胞肺癌患者,所有患者未行手术治疗,以NLR中位数将患者分为高NLR组和低NLR组,对可能影响患者预后的各项因素进行分析。结果 47例病人获得随访。47例患者中1年生存率为53.2%。其中低NLR组的病人1年生存率为83.3%;高NLR组病人1年生存率为21.7%,单因素分析显示小细胞肺癌患者的预后与患者的分期、体力状况ECOG评分以及NLR水平相关(均有P0.05),对与预后相关的变量进行COX多因素分析,结果显示分期处于广泛期和高NLR水平是影响患者预后的独立危险因素(均有P0.05)。结论 NLR可能是小细胞肺癌患者预后的独立危险因素。
[Abstract]:Objective to explore the treatment of peripheral blood neutrophil to lymphocyte ratio (neutrophil-to-lymphocyte, ratio, NLR) and small cell lung cancer patients. Methods a retrospective analysis of January 2013 ~2015 in the First Affiliated Hospital of Medical University Of Anhui in March with pathological diagnosis of 50 cases of small cell lung cancer patients, all patients without surgical treatment, with the median of NLR patients for the high NLR group and low NLR group, on the factors which may influence the prognosis of the patients were analyzed. Results 47 cases were followed up for.47 patients 1 year survival rate was 53.2%. in low NLR group of patients 1 year survival rate was 83.3%; the high NLR group of patients 1 year survival rate was 21.7%, single factor analysis show the stage and prognosis of patients with non-small cell lung cancer, ECOG performance status and NLR level (all P0.05), COX is used to analyze the multi factors on the prognosis and the related variables, the results show Conclusion: extensive stage and high NLR level are independent risk factors affecting prognosis of patients (all P0.05). Conclusion NLR may be an independent risk factor for prognosis of patients with small cell lung cancer.

【作者单位】：安徽医科大学第一附属医院肿瘤内科;
【基金】：安徽省科技厅对外科技合作计划(1503062023)
【分类号】：R734.2

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