糖基转移酶超家族在肿瘤转移中的作用

发布时间：2018-04-19 03:18

本文选题：唾液酰基转移酶 + 岩藻糖基转移酶　；参考：《生物化学与生物物理进展》2017年10期

【摘要】：蛋白质的糖基化修饰主要包括N-连接糖基化、O-连接糖基化和糖基磷脂酰肌醇锚定连接.与核酸和蛋白质不同,糖链的合成过程并不遵循传统的基因信息传递的中心法则,主要由一系列催化糖苷键形成的糖基转移酶完成.异常糖基化修饰被认为与恶性肿瘤的发生发展和临床预后密切相关.研究表明,糖基转移酶的表达及其糖链结构的异常可通过调节肿瘤细胞与细胞外基质的相互作用,继而影响肿瘤转移的关键步骤,如上皮间质转化(E-钙黏着蛋白、N-钙黏着蛋白)、细胞的移动性(整合素β1和α5)、侵袭(基质金属蛋白酶MMPs)、浸润(唾液酸化Lewis抗原sLeX和sLeA).本文主要就唾液酰基转移酶、岩藻糖基转移酶和N-乙酰氨基葡萄糖转移酶等三大糖基转移酶家族的结构和生物学功能及其在肿瘤转移中的作用作一综述,以期为肿瘤转移的预测和诊断提供新思路.
[Abstract]:The glycosylation modification of proteins mainly includes N-linked glycosylation, O-linked glycosylation and glycosylphosphatidylinositol anchoring.Unlike nucleic acids and proteins, the synthesis of sugar chains does not follow the central principle of traditional gene information transmission, and is mainly accomplished by a series of glycosyltransferases that catalyze the formation of glycosides.Abnormal glycosylation modification is thought to be closely related to the occurrence, development and clinical prognosis of malignant tumors.It has been shown that the expression of glycosyltransferase and the abnormal structure of glycosyltransferase may affect the key steps of tumor metastasis by regulating the interaction between tumor cells and extracellular matrix.For example, epithelial mesenchymal transformation, E-cadherin, N-cadherin, cell mobility (integrin 尾 _ 1 and 伪 _ 5), invasion (matrix metalloproteinase (MMP), invasion (salivary acidated Lewis antigen sLeX and sLeA).In this paper, the structure and biological functions of salivary acyltransferase, fucosyltransferase and N-acetylglucosaminyltransferase family and their roles in tumor metastasis were reviewed.In order to provide a new way for the prediction and diagnosis of tumor metastasis.
【作者单位】：大连理工大学生命与医药学院;大连医科大学生物化学与分子生物学教研室糖生物学研究所;
【基金】：国家重点基础研究发展计划(2012CB822103) 国家自然科学基金(31470799)项目资助~~
【分类号】：R73-37

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