环境危险因素暴露对儿童急性淋巴细胞白血病发生风险的影响

发布时间：2018-04-19 17:56

本文选题：白血病 + 双表型　；参考：《中华疾病控制杂志》2017年04期

【摘要】：目的探索儿童环境危险因素对儿童急性淋巴细胞白血病(acute lymphoblastic leukemia,ALL)发生风险的影响。方法采用病例-对照研究的流行病学方法,收集2015年在天津市血液病医院就诊的儿童ALL作为病例组,选取同期同地区的健康儿童作为对照组。通过一对一问卷调查的方式收集研究对象的相关信息。通过单因素x~2检验和多因素非条件Logistic回归模型,分析儿童环境危险因素与ALL发生关联情况,并计算相关危险因素的人群归因危险度百分比(population attributable risk percent,PARP)。结果单因素分析结果显示,病例组中接触油漆涂料(x~2=7.146,P=0.008)、不爱吃蔬菜和水果(x~2=47.070,P0.001)以及出生后居室装修(x~2=9.030,P=0.003)的儿童发生ALL的比例均高于对照组。多因素分析结果显示,接触油漆涂料(OR=2.174,95%CI:1.031~4.583)、不爱吃蔬菜和水果(OR=4.990,95%CI:3.017~8.253)和出生后居室装修(OR=2.831,95%CI:1.361~5.889)与儿童ALL的发生相关。上述三种危险因素的PARP分别为11.2%、25.2%和11.7%。结论油漆涂料接触史、不爱吃蔬菜和水果及出生后居室装修可能是儿童患ALL的危险因素。
[Abstract]:Objective to explore the effect of environmental risk factors on the risk of acute lymphoblastic leukemia (ALL) in children with acute lymphoblastic leukemia.Methods the epidemiological method of case-control study was used to collect children ALL from Tianjin Hematological Hospital in 2015 as case group and healthy children in the same period as control group.The information of the subjects was collected by one-to-one questionnaire.Single factor x2 test and multivariate non-conditional Logistic regression model were used to analyze the association between environmental risk factors and ALL in children, and to calculate the population attributable risk percentage of population attributable risk of related risk factors.Results the results of univariate analysis showed that the incidence of ALL in children exposed to paint paint (27.146) and not eating vegetables and fruits (47.070) and postnatal room decoration (9.030) was significantly higher than that in control group (P 0.003).The results of multivariate analysis showed that the contact with paint paint (OR 2.174 / 95 CI: 1.031) was associated with the occurrence of ALL in children. It did not like to eat vegetables and fruits (4.990) and CI3.017 (8.253) and the post birth decoration of the bedroom (2.831 / 95 CIW 1.3615.889) was associated with the occurrence of ALL in children.The PARP of the above three risk factors were 11.2g / 25.2% and 11.7g, respectively.Conclusion the history of paint and paint exposure, the dislike of vegetables and fruits, and the indoor decoration after birth may be the risk factors of ALL in children.
【作者单位】：天津市疾病预防控制中心环境与健康室;中国医学科学院血液病医院儿科;
【基金】：国家自然科学基金(81200396) 天津市卫生计生委科技基金(2014KR12) 天津市疾病预防控制中心科技基金(CDCKY1406)
【分类号】：R733.71

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