血小板参数在乳腺癌患者早期诊断中的价值

发布时间：2018-04-19 19:28

本文选题：乳腺肿瘤 + 血小板　；参考：《重庆医学》2017年06期

【摘要】：目的探讨血小板参数测定在乳腺癌早期诊断中的应用价值。方法回顾性分析2015年1-12月该院收治的103例乳腺癌患者与117例纤维腺瘤患者入院24h内的静脉血血小板参数,包括血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、平均血小板内容物浓度(MPC)、平均血小板内容物含量(MPM)、血小板分布宽度(PDW),与100例同期健康体检人群作对照组进行比较,并绘制ROC曲线评价血小板各参数的诊断效能。结果与对照组相比,纤维腺瘤组和乳腺癌组的PLT、PCT显著增高(P0.01),MPC、MPM、PDW显著降低(P0.01),MPV差异无统计学意义(P0.05);与纤维腺瘤组相比,乳腺癌组的MPC明显降低,差异有统计学意义(P0.01)。MPC用于诊断乳腺癌的ROC曲线下面积最高(AUC=0.841),当诊断临界值为249.5g/L时,敏感性为82.5%,特异度为73.6%。结论血小板参数的检测,尤其是MPC,对乳腺癌的早期诊断具有一定的应用价值。
[Abstract]:Objective to evaluate the value of platelet parameter determination in early diagnosis of breast cancer. Methods the venous platelet parameters of 103 patients with breast cancer and 117 patients with fibroadenoma from January to December 2015 were analyzed retrospectively. It included platelet count (PLT), platelet pressure accumulation (PCT), mean platelet volume (MPV), mean platelet content (MPPC), mean platelet content (MPM), platelet distribution width (PDW), and control group (n = 100). ROC curves were plotted to evaluate the diagnostic efficacy of platelet parameters. Results compared with the control group, the level of MPC in the fibroadenoma group and breast cancer group was significantly higher than that in the control group, and the MPC in the breast cancer group was significantly lower than that in the fibroadenoma group. The difference was statistically significant (P 0.01). MPC was used to diagnose breast cancer with the highest area under the ROC curve. When the diagnostic critical value was 249.5g/L, the sensitivity was 82.5 and the specificity was 73.6. Conclusion Detection of platelet parameters, especially MPCs, is valuable for early diagnosis of breast cancer.
【作者单位】：广东省妇幼保健院检验科;
【分类号】：R737.9;R730.43

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