血清CA125、HE4联合阴道彩色多普勒在卵巢癌高危人群早期筛查中的临床价值

发布时间：2018-04-24 04:21

本文选题：卵巢癌高危人群 + CA　；参考：《重庆医学》2017年12期

【摘要】：目的探讨血清癌胚抗原125(CA125)、人附睾蛋白4(HE4)联合阴道彩色多普勒检查在卵巢癌高危人群早期筛查中的临床价值。方法将纳入研究的对象分为3组:健康组100例,高危组80例,卵巢癌组32例。对比3组血清CA125、HE4水平及超声评分。结果卵巢癌组HE4和CA125水平及超声评分较其他两组明显升高,差异有统计学意义(P0.01);高危组的阳性检出率及CA125水平均高于健康组,差异均有统计学意义(P0.05);高危组中,CA125、HE4联合超声的阳性检出率均高于其他检测方法(P0.05);CA125+HE4联合阴道超声筛查的敏感性及特异性明显高于其他筛查方法,差异有统计学意义(P0.05);HE4特异性明显高于CA125,但敏感性低于CA125(P0.05)。结论 CA125、HE4联合阴道超声检查有利于提高卵巢癌高危人群的早期筛查,便于节约医疗成本,提高检出率。
[Abstract]:Objective to evaluate the clinical value of serum carcinoembryonic antigen 125 (CA125) and human epididymal protein (4) in combination with vaginal color Doppler examination in early screening of high risk population of ovarian cancer. Methods the subjects were divided into three groups: healthy group (100 cases), high risk group (80 cases) and ovarian cancer group (32 cases). The serum CA125 HE4 levels and ultrasound scores were compared among the 3 groups. Results the levels of HE4 and CA125 and ultrasound score in ovarian cancer group were significantly higher than those in the other two groups, the difference was statistically significant (P 0.01), the positive detection rate and CA125 level in high risk group were higher than those in healthy group. The positive rate of CA125HE4 combined with ultrasound in high risk group was higher than that of other methods. The sensitivity and specificity of CA125 HE4 combined with vaginal ultrasound screening were significantly higher than those of other screening methods. The difference was statistically significant (P 0.05), but the sensitivity was lower than that of CA125 (P 0.05), but the specificity was higher than that of CA 125 (P 0.05), but the sensitivity was lower than that of CA 125 (P 0.05). Conclusion CA125 He-4 combined with vaginal ultrasound is helpful to improve the early screening of high risk population of ovarian cancer, to save medical cost and to improve the detection rate.
【作者单位】：江苏省淮安市妇幼保健院更年期门诊;江苏省淮安市妇幼保健院麻醉科;
【基金】：江苏省淮安市科技计划项目——应用研究与科技攻关计划(社会发展)课题基金(HAS2014)
【分类号】：R737.31

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