幽门螺杆菌感染与大肠肿瘤的发生及临床病理特点的关系

发布时间：2018-04-26 09:07

本文选题：幽门螺杆菌 + 感染　；参考：《中华医院感染学杂志》2017年24期

【摘要】：目的探讨幽门螺杆菌感染与大肠肿瘤的发生及其临床病理特点的关系,为幽门螺杆菌在大肠肿瘤发病中的作用提供依据。方法选择2014年1月-2016年12月医院收治的大肠癌患者70例作为大肠癌组,大肠腺瘤患者70例作为大肠腺瘤组,结直肠镜及组织病理学结果正常者70名作为对照组;统计分析三组临床病理特点资料。结果大肠癌组和大肠腺瘤组幽门螺杆菌感染率分别为68.6%、71.4%,高于对照组的51.4%(P0.05);大肠癌组患者幽门螺杆菌感染与患者的性别、年龄、肿瘤大小、病理分级、病理类型、淋巴结转移无关;大肠腺瘤组患者幽门螺杆菌感染与患者性别、年龄、肿瘤大小、肿瘤数目、肿瘤蒂部情况、肿瘤病理分型无关。结论幽门螺杆菌感染与大肠癌及大肠腺瘤的发生有关,但与大肠癌及大肠腺瘤的临床病理特点无关。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori infection and the occurrence and clinicopathological characteristics of colorectal tumors and to provide evidence for the role of Helicobacter pylori in the pathogenesis of colorectal tumors. Methods from January 2014 to December 2016, 70 patients with colorectal cancer, 70 patients with colorectal adenoma and 70 patients with normal colonoscopy and histopathology were selected as colorectal cancer group, colorectal adenoma group and control group. The clinicopathological data of the three groups were statistically analyzed. Results the infection rate of Helicobacter pylori in colorectal cancer group and colorectal adenoma group was 68.6% and 71.4, respectively, which was higher than that in control group (51.4%), and there was no correlation between Helicobacter pylori infection and sex, age, tumor size, pathological grade, pathological type, lymph node metastasis in colorectal cancer group. Helicobacter pylori infection in colorectal adenoma group was not related to sex, age, tumor size, tumor number, tumor pedicle, pathological type of tumor. Conclusion Helicobacter pylori infection is associated with colorectal cancer and colorectal adenoma, but not with clinicopathological features of colorectal cancer and colorectal adenoma.
【作者单位】：杭州市余杭区第五人民医院消化内科;
【基金】：浙江省医药卫生基金资助项目(2014KYB226)
【分类号】：R573;R735.34

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