单侧隐睾与对侧睾丸癌相关性的系统评价

发布时间：2018-04-26 09:21

  本文选题：隐睾 + 睾丸癌　； 参考：《新疆医科大学》2015年硕士论文

【摘要】：目的：系统评价单侧隐睾与对侧睾丸癌的相关性,为临床研究及实践提供参考。方法：计算机检索PubMed、EMbase、WanFang Data、CNKI、Cochrane和CBM数据库,检索年限为1980年至今,收集所有单侧隐睾与对侧睾丸癌相关性的队列研究及病历对照研究的文献。要求符合隐睾及睾丸癌相关性研究,并能提供具体数据的文献。由3名质量控制员按照设定的纳入标准和排除标准检测相关的参考文献,进行质量评价和资料提取。应用RevMan5.2版软件进行数据的Meta分析处理；本系统评价疗效资料均为分类变量,故以相对危险度或比值比(RR或OR)及其95%可信区间(95%CI)来表示变量。结果：共检索出文献1630篇,符合要求12篇,排除7篇,其中符合要求的5篇纳入此meta分析。结果共涉及5个病例对照研究,男性隐睾症138例,86(62%)在同侧和52(38%)在对侧。合并的相对危险度在同侧和对侧睾丸癌中分别为：[OR=3.04,95% CI(1.88,4.91),P=0.15]和[OR=1.98,95% CI (1.12,3.50), P=0.09]。结论：单侧隐睾导致睾丸癌的风险在双侧睾丸均会增加,但同侧风险会高于对侧。因为受纳入研究数量和质量的限制,上述结论尚有赖于进一步开展更多大样本、多中心、高质量的队列研究加以验证。
[Abstract]:Objective: to evaluate the correlation between unilateral cryptorchidism and contralateral testicular carcinoma and to provide reference for clinical study and practice. Methods: a computer-based search was carried out on PubMedus EMbase Fang data (CNKI) Cochrane and CBM databases for the period from 1980 to present. All the cohort studies on the correlation between unilateral cryptorchidism and contralateral testicular carcinoma and the comparative study of medical records were collected. It is required to be consistent with the study of the association of cryptorchidism and testicular carcinoma, and to provide specific data in the literature. The quality evaluation and data extraction were carried out by three quality controllers according to the relevant reference documents of inclusion standard and exclusion standard test. The RevMan5.2 software was used to analyze and process the data. The data of the system were classified variables, so the relative risk or ratio of RR or ORs and 95% confidence interval (95% CI) were used to represent the variables. Results: a total of 1630 articles were retrieved, 12 were in accordance with the requirements, 7 were excluded, 5 of which were included in the meta analysis. Results A total of 5 case-control studies were conducted. 138 cases of male cryptorchidism were located on the ipsilateral side and 52 on the contralateral side. The relative risk of concomitant testicular carcinoma in ipsilateral and contralateral testicular carcinoma was: [ORO 3.04% 95% CI 1.88 卤4.91 P0. 15] and [ORL 1.98 95% CI 1.12 + 3.50, P0. 09]. Conclusion: the risk of testicular carcinoma caused by unilateral cryptorchidism is increased in both testes, but the ipsilateral risk is higher than that of contralateral testicular carcinoma. Because of the limitation of the quantity and quality of the study, the above conclusions depend on further large sample, multi-center, high-quality cohort study to verify.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.21
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本文编号：1805408