前列腺癌间歇内分泌治疗的研究进展

发布时间：2018-04-26 23:26

本文选题：前列腺癌 + 间歇内分泌治疗　；参考：《重庆医科大学》2017年硕士论文

【摘要】：前列腺癌是泌尿外科常见恶性肿瘤,近年来发病率逐年上升,严重影响男性的健康,在世界范围内已成为一个被广泛关注的公共健康问题。由于前列腺癌细胞的分化、生长和增殖依赖于雄激素的刺激,剥夺前列腺癌细胞的雄激素的刺激可引起肿瘤细胞的凋亡,任何去除和抑制雄激素活性的治疗都可称为内分泌治疗,因此内分泌治疗在前列腺癌的治疗中占有重要地位,根据其治疗的持续时间可分为间歇内分泌治疗和持续内分泌治疗;本文结合动物实验模型、近期相关临床研究进展和国内外最新指南,对前列腺癌的间歇及持续内分泌治疗的疗效及副作用进行了比较和分析,并对间歇内分泌治疗的研究进展作一阐述。
[Abstract]:Prostate cancer is a common malignant tumor in the Department of urology. In recent years, the incidence of the disease has been increasing year by year. It has seriously affected the health of men and has become a widespread public health problem in the world. The growth and proliferation of prostate cancer cells depend on androgen stimulation and deprive the androgen stimulation of prostate cancer cells. It can cause apoptosis of tumor cells. Any treatment for removing and inhibiting androgen activity can be called endocrine therapy. Therefore, endocrine therapy plays an important role in the treatment of prostate cancer. According to the duration of its treatment, it can be divided into intermittent endocrine therapy and continuous endocrine therapy. The progress of clinical research and the latest guidelines at home and abroad are compared and analyzed for the efficacy and side effects of intermittent and continuous endocrine therapy for prostate cancer, and the research progress of intermittent endocrine therapy is described.

【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.25

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