多指标联合检测在小细胞肺癌诊断中的应用价值研究

发布时间：2018-04-28 14:36

本文选题：小细胞肺癌 + 癌胚抗原　；参考：《河北医科大学》2015年硕士论文

【摘要】：目的:探讨血清肿瘤标志物CEA、NSE和Pro GRP与免疫组化指标Syn、CD56、Cg A,Ki-67在小细胞肺癌诊断中的关系。方法:应用电化学发光技术和化学发光技术检测48例小细胞肺癌患者血清标志物CEA、NSE和Pro GRP的浓度;采用Max Vision免疫组化技术检测Syn、CD56、Cg A,Ki-67;用χ2检验、两独立样本非参数检验、等级相关Spearman’s检验分析结果。结果:1小细胞肺癌免疫组化Syn、CD56、Cg A表达阳性率高于血清CEA,P0.001差异有统计学意义。免疫组化Syn、CD56、Cg A表达阳性率与血清NSE、Pro GRP比较,无显著性差异。2 Ki-67增殖程度与血清肿瘤标志物CEA、NSE、Pro GRP等浓度之间均有负相关关系,r值分别为-0.445、-0.065、-0.130;P值分别为0.001、0.001、0.001。P值均0.05有统计学意义。3局限期与广泛期免疫组化指标阳性率表达无统计学意义;广泛期血清肿瘤标志物CEA、NSE、Pro GRP浓度均高于局限期,Z值分别为-5.760、-10.833、-12.076;P值均为P0.001,P0.05差异有统计学意义。结论:1 NSE和Pro GRP在诊断SCLC时优于CEA。而免疫组化Syn、CD56、Cg A表达阳性率与血清NSE、Pro GRP阳性率比较却没有明显优势。2 SCLC Ki-67增殖程度与血清肿瘤标志物CEA、NSE、Pro GRP浓度之间均有负相关关系。3 SCLC广泛期血清肿瘤标志物CEA、NSE、Pro GRP浓度均高于局限期。
[Abstract]:Objective: to investigate the relationship between serum tumor markers CEA NSE and Pro GRP and immunocytochemical marker Syngma CD56 C g Agii Ki-67 in the diagnosis of small cell lung cancer (SCLC). Methods: electrochemiluminescence and chemiluminescence techniques were used to detect the concentrations of serum markers CEANANSE and Pro GRP in 48 patients with small cell lung cancer, Max Vision immunohistochemical technique was used to detect the levels of CD56 Cg Agni Ki-67, and 蠂 2 test was used to detect the nonparametric test of two independent samples. Grade correlation Spearman's test results. Results the positive rate of CD56 C g A expression in small cell lung cancer was significantly higher than that in serum CEA P0.001. The positive rate of immunocytochemical expression of CD56 CGA was compared with that of serum NSEP Pro GRP. There was no significant difference between the proliferative degree of Ki-67 and the concentration of serum tumor marker CEA NSEP GRP. R values were -0.445U -0.065U -0.130 (P = 0.001n 0.001N 0.001.P respectively). The rate of expression was not statistically significant. The concentration of serum tumor marker CEA NSEP GRP was significantly higher than that of localized stage (Z = -5.760) -10.833% -12.076 (P < 0.05). Conclusion 1 NSE and Pro GRP are superior to CEA in the diagnosis of SCLC. However, there was no significant correlation between the positive rate of immunocytochemistry and the positive rate of serum NSEP GRP. 2. 2 SCLC Ki-67 proliferative degree and the concentration of serum tumor marker CEA NSEP GRP. 3 SCLC in the extensive stage of serum tumor marker CEA NSEP Pro, there was no significant correlation between the positive rate of immunohistochemistry and the positive rate of serum NSEP. The concentration of GRP was higher than the local deadline.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R734.2

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