乳腺癌特殊部位转移68例临床特征及预后分析

发布时间：2018-04-29 15:08

本文选题：乳腺肿瘤 + 转移性乳腺癌　；参考：《肿瘤》2017年02期

【摘要】：目的 :分析特殊部位转移的乳腺癌的临床病理特征及预后。方法 :回顾性分析2012—2015年68例伴特殊部位转移的乳腺癌患者的临床资料。特殊转移部位的定义:除淋巴结、胸壁、乳腺、骨、肝、肺、脑、腹膜和胸膜转移以外的少见转移部位。结果:68例患者中,最常见的特殊转移部位依次为肾上腺(44.1%,30/68)、卵巢(41.2%,28/68)和胰腺(11.8%,8/68),其余包括眼、子宫、脾、直肠、膀胱、肾、甲状腺和腮腺等。75.0%(51/68)的患者伴有其他常见部位的转移。特殊部位转移后的中位生存时间为23.5个月(范围:1.4~116.0个月),不伴有常见部位转移患者的中位生存时间与伴有常见部位转移患者相比,前者显示出生存优势(分别为36.0和18.0个月,P=0.007)。结论 :乳腺癌转移部位广泛,除常见转移部位以外,还可以转移至许多少见部位;不伴有常见部位转移的特殊部位转移乳腺癌患者的预后较好,因此有选择性地进行局部治疗可能会改善生存;卵巢转移大多于去势手术时发现,临床上在选择卵巢去势方式时,应考虑卵巢转移的可能性。
[Abstract]:Objective: to analyze the clinicopathological features and prognosis of breast cancer with special site metastasis. Methods: the clinical data of 68 breast cancer patients with special site metastasis from 2012 to 2015 were analyzed retrospectively. Definition of special metastatic sites: rare metastatic sites other than lymph nodes, chest walls, mammary glands, bone, liver, lung, brain, peritoneum, and pleural metastases. Results among 68 patients, the most common special metastases were the adrenal gland 44.1 / 68, the ovary 41.2 / 68) and the pancreas 11.8 / 68. The rest included eyes, uterus, spleen, rectum, bladder, kidney, thyroid, parotid gland, etc. The median survival time of the patients with special site metastasis was 23.5 months (range: 1.4 ~ 116.0 months). The median survival time of the patients without common site metastasis showed a survival advantage (36.0 and 18.0 months, respectively) compared with that of the patients with common site metastasis (36.0 and 18.0 months, respectively). Conclusion: the metastatic sites of breast cancer are extensive and can be transferred to many rare sites in addition to the common metastatic sites. Therefore selective local treatment may improve survival and ovarian metastases are mostly found in ovariectomies and the possibility of ovarian metastasis should be taken into account when selecting ovariectomized methods in clinic.
【作者单位】：北京大学肿瘤医院暨北京市肿瘤防治研究所乳腺肿瘤内科恶性肿瘤发病机制及转化研究教育部重点实验室;安徽省阜阳市第二人民医院肿瘤科;
【分类号】：R737.9

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