阑尾切除与随后发生结肠癌的相关性

发布时间：2018-04-30 21:17

本文选题：阑尾切除术 + 结肠癌　；参考：《延边大学》2017年硕士论文

【摘要】：目的探讨阑尾切除与发生结肠癌的关系,分析阑尾切除术后发生结肠癌的危险因素,为临床防治结肠癌提供参考资料。方法选取1996年1月-2006年1月延边医院收治的40岁阑尾切除术患者2530例作为观察组,另随机选取同期本院门诊40岁健康体检人群2643例为对照组,全部患者进行10年随访,观察组实际应答率97.08%(2456/2530),对照组实际应答率94.59%(2500/2643)。分别记录患者一般情况(如性别等)、生活习惯(吸烟饮酒史、体育锻炼、每周排便次数等)、家属恶性肿瘤史等资料。结果(1)观察组患者10年内结肠癌发生率是3.62%,对照组为0.12%,两组比较有统计学差异(P0.05);说明阑尾切除会增加结肠癌的发病率。(2)全部随访人群按有无结肠癌分组,分别从性别、饮酒史、体育锻炼情况、每周大便频次、一级亲属恶性肿瘤史等方面对结肠癌相关危险因素进行单因素分析,结果显示除吸烟因素外,其他因素结肠癌组明显高于无结肠癌组。比较统计学差异(均P0.05)。(3)通过分层分析方法,分析上述结肠癌危险因素对于阑尾切除与结肠癌发生关系的影响,观察组与对照组分别从性别、饮酒史、体育锻炼情况、每周大便频次、一级亲属恶性肿瘤史等方面比较,排除上述危险因素的影响后,P0.05仍成立,说明阑尾切除对于结肠癌发生的影响,不受性别、饮酒史、体育锻炼情况、每周大便频次及一级亲属恶性肿瘤史的影响。(4)经多元Logistic回归分析,阑尾切除、性别、饮酒史、体育锻炼情况、每周大便频次及一级亲属恶性肿瘤史等均是结肠癌的独立危险因素。结论阑尾切除术后患者10年内发生结肠癌的风险增加;阑尾切除与性别、饮酒、不常锻炼、大便频次3次/周或大于14次/周,以及一级亲属有恶性肿瘤史等因素均是结肠癌的独立危险因素。
[Abstract]:Objective to explore the relationship between appendectomy and colon cancer, and to analyze the risk factors of colon cancer after appendectomy, and to provide reference for clinical prevention and treatment of colon cancer. Methods 2530 patients with 40 years old appendectomy treated in Yanbian Hospital from January 1996 to January 2006 were selected as observation group. 2643 healthy people aged 40 years were randomly selected as control group. All the patients were followed up for 10 years. The actual response rate of the observation group was 97.08 and that of the control group was 94.599.00 / 2643. The patients' general condition (such as gender, life habits, smoking and drinking history, physical exercise, defecation times per week, family history of malignancy and so on) were recorded separately. Results 1) the incidence of colon cancer was 3.62 in the observation group and 0.12 in the control group. There was a statistical difference between the two groups, indicating that appendectomy would increase the incidence of colon cancer. Univariate analysis of the risk factors related to colon cancer was carried out from the aspects of physical exercise frequency of defecation per week and history of malignant tumors of first-degree relatives. The results showed that the risk factors of colon cancer were significantly higher in colon cancer group than in non-colon cancer group except smoking factors. The influence of the risk factors of colon cancer on the relationship between appendectomy and colon cancer was analyzed by stratified analysis. The study group and control group were divided into three groups: sex, drinking history and physical exercise. The frequency of stool per week, history of malignant tumors of first-degree relatives and so on were compared. After excluding the influence of the above-mentioned risk factors, P0.05 was still valid, which showed that appendectomy had an effect on the occurrence of colon cancer, not affected by sex, history of drinking alcohol, physical exercise, etc. The influence of weekly defecation frequency and the history of malignant tumor of first-degree relatives. 4) by multiple Logistic regression analysis, appendectomy, sex, drinking history, physical exercise, etc. Weekly defecation frequency and first-degree relatives' history of malignancy were independent risk factors for colon cancer. Conclusion the risk of colon cancer is increased in 10 years after appendectomy, the risk of appendectomy and sex, drinking alcohol, not exercising frequently, defecation frequency 3 times per week or more than 14 times per week. Factors such as history of malignancy in first degree relatives were independent risk factors for colon cancer.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.35;R656.8

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