MSA、CEA、NLR联合检测对小细胞肺癌的诊断及鉴别诊断效能

发布时间：2018-05-01 23:32

本文选题：小细胞肺癌 + 抗纺锤体抗体　；参考：《山东医药》2017年47期

【摘要】：目的观察血清抗纺锤体抗体(MSA)、癌胚抗原(CEA)及全血中性粒细胞/淋巴细胞(NLR)联合检测对小细胞肺癌(SCLC)的诊断和鉴别诊断效能。方法 SCLC患者53例(SCLC组)、肺腺癌(LAC)患者33例(LAC组)、肺鳞癌(LSC)患者29例(LSC组)、胃癌(GC)患者16例(GC组)、肝癌(HC)患者14例(HC组)、大肠癌(IC)患者13例(IC组)、鼻咽癌(NC)患者12例(NC组),另选健康体检者45例(对照组),采用间接免疫荧光法检测血清MSA,化学发光法检测血清CEA,电阻抗法测算全血NLR,分析MSA、CEA、NLR单独和联合检测诊断SCLC的敏感度、特异度。结果与其余组比较,SCLC组血清MSA阳性率高;与SCLC组比较,LAC组血清CEA、全血NLR阳性率高,对照组血清CEA、全血NLR阳性率低;P均0.05。NLR单独检测诊断SCLC的灵敏度最高(43.40%),MSA单独检测诊断的特异度最高(96.58%)。MSA+CEA+NLR三者联合检测诊断SCLC的敏感度(并联,81.84%)、特异度(串联,100.00%)最高。MSA与CEA一致性较高(κ=0.654);MSA与NLR一致性中等(κ=0.451)。结论血清MSA、CEA及全血NLR联合检测有助于SCLC的诊断和鉴别诊断。
[Abstract]:Objective to observe the diagnostic and differential diagnostic efficacy of serum anti-spindle antibody (MSAA), carcinoembryonic antigen (CEA) and whole blood neutrophil / lymphocyte (NLRR) in the diagnosis and differential diagnosis of small cell lung cancer (SCLC). Methods A total of 53 cases of SCLC, 33 cases of lung adenocarcinoma, 33 cases of SCLC, 29 cases of lung squamous cell carcinoma, 16 cases of gastric carcinoma, 14 cases of SCLC, 14 cases of HC, 13 cases of colorectal carcinoma, 13 cases of nasopharyngeal carcinoma, and 13 cases of carcinoma of large intestine were studied. Serum MSA was detected by indirect immunofluorescence assay, serum CEA was detected by chemiluminescence method, NLRs of whole blood were measured by electrical impedance method, and the sensitivity of SCLC was analyzed by single and combined detection of NLR in 12 cases of NC group and 45 cases of healthy control group (control group). Specificity. Results compared with the other groups, the positive rate of serum MSA was higher in the control group, and the positive rate of NLR in the whole blood was higher in the SCLC group than in the SCLC group. In the control group, the positive rate of NLR in whole blood was lower than that in the control group. The sensitivity of 0.05.NLR alone in the diagnosis of SCLC was 43.40%. The highest specificity of MSA was 96.5858%. MSA CEA NLR was the most sensitive in the diagnosis of SCLC (shunt 81.84%) and specificity (100.00g in series). The consistency between MSA and CEA was high (魏 0. 654) and the consistency between MSA and NLR was moderate (魏 0. 451). Conclusion the combined detection of serum MSA-CEA and whole blood NLR is helpful for the diagnosis and differential diagnosis of SCLC.
【作者单位】：南昌大学第二附属医院;南昌大学公共卫生学院;
【基金】：江西省科技计划项目(20151BBI90047,20171BAB205076)
【分类号】：R734.2

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