XRCC3 Thr241Met基因多态性与胃癌易感性的Meta分析

发布时间：2018-05-02 13:07

本文选题：胃肿瘤 + XRCC　；参考：《现代肿瘤医学》2017年05期

【摘要】：目的:综合评价X线修复交叉互补基因3(X-ray repair cross-complementing group 3,XRCC3)Thr241Met单核苷酸基因多态性与胃癌易感性的关系。方法:计算机检索相关期刊论文(CNKI)、中国生物医学文献数据库(CBM)、中文科技期刊全文数据库(VIP)、万方数据库、Pub Med、Cochrane Library,收集国内外公开发表的关于XRCC3 Thr241Met基因多态性与胃癌易感性的病例-对照研究相关文献。采用Stata12.0软件进行统计学分析,计算合并比值比(odd ratio,OR)及95%可信区间(confidence interval,CI)。结果:共纳入12篇文献,从总的效应量分析,XRCC3 Thr241Met基因多态性与胃癌易感性间无明显相关性,按种族进行亚组分析,提示在亚洲人群中隐性模型(MM vs MT+TT:OR=2.59,95%CI:1.98~3.39,P0.001)、等位模型(M vs T:OR=1.57,95%CI:1.05~2.35,P=0.028)、纯合子模型(MM vs TT:OR=3.39,95%CI:2.17~5.31,P0.001)均具有统计学意义。基于对照组来源及是否符合Hardy-Weinberg遗传平衡进行的亚组分析结果提示突变型与野生型无明显统计学意义。结论:在亚洲人群中,XRCC3 Thr241Met基因多态性可能与胃癌易感性有关。
[Abstract]:Objective: to evaluate the association of single nucleotide polymorphisms of 3(X-ray repair cross-complementing group 3rCC3hthr241Met gene with susceptibility to gastric cancer. Methods: to search the full text database of Chinese periodicals (CNKI), Chinese Biomedical Literature Database (CBM), Chinese Sci-tech Journal Full-text Database (XRCC3 Thr241Met), Pub MedCochrane Library, and collect the published data on the polymorphism of XRCC3 Thr241Met gene at home and abroad. Case-control study of gastric cancer susceptibility. Statistical analysis was carried out with Stata12.0 software. The combined ratio was calculated as odd ratioor) and 95% confidence intervalescence. Results: there was no significant correlation between the polymorphism of XRCC3 Thr241Met gene and the susceptibility of gastric cancer. It is suggested that in Asian population, the hidden model (MM vs MT TTW OR2.5995) has statistical significance, and the allelic model (M vs TW OR 1.5795) has statistical significance, and the homozygous model (MM vs TTW OR3.3995 CI2.175.31 / P0.001) has statistical significance. The results of subgroup analysis based on the origin of control group and the genetic balance of Hardy-Weinberg showed that there was no significant difference between the mutant and the wild type. Conclusion: the polymorphism of XRCC3 Thr241Met gene may be associated with gastric cancer susceptibility in Asian population.
【作者单位】：兰州大学第一医院肿瘤外科;
【基金】：甘肃省科技支撑计划项目(编号:1504FKCA084) 甘肃省卫生行业科研计划项目(编号:GSWST2013-16)
【分类号】：R735.2

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