血液HSP90α、CEA、NSE、CYFRA21-1及SCCA联合检测对肺癌的诊断价值研究

发布时间：2018-05-04 10:03

本文选题：热休克蛋白α + 癌胚抗原　；参考：《中国现代医学杂志》2017年12期

【摘要】：目的评价血液热休克蛋白90α(HSP90α)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)及鳞状细胞癌抗原(SCCA)在肺癌(LC)中的诊断价值。方法将LC患者分为鳞癌(LAC)、腺癌(LSC)及小细胞癌(SCLC)3组,比较各组标志物。结果 SCLC组HSP90α、CEA、NSE及CYFRA21-1较对照组增高,HSP90α高于LAC组和LSC组;LAC组HSP90α、NSE、CYFRA21-1及SCCA较对照组增高,SCCA高于SCLC组和LSC组;LSC组HSP90α和CEA较对照组增高;HSP90α的受试者工作特征曲线下面积最大。串联分析HSP90α+NSE+CYFRA21-1可提高SCLC的特异性、阳性预测值及正确分类率,HSP90α+NSE+CYFRA21-1+SCCA和HSP90α+CEA可分别提高LAC、LSC的特异性和阳性预测值,正确分类率为理想水平。结论 HSP90是筛查LC的理想指标;联合检测HSP90α等5种标志物有助于LC的分层诊断。
[Abstract]:Objective to evaluate the diagnostic value of heat shock protein 90 伪 (HSP90 伪), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 (CYFRA21-1) and squamous cell carcinoma antigen (SCCA) in lung cancer. Methods LC patients were divided into three groups: squamous cell carcinoma (LC), adenocarcinoma (LSCC) and small cell carcinoma (SCLC). Results compared with the control group, the HSP90 伪 CEASE and CYFRA21-1 in SCLC group were higher than those in LAC group and LSC group. The area under the operating characteristic curve of SCLC group was higher than that of SCLC group and LSC group. The area under the operating characteristic curve of SCLC group was higher than that of LAC group and LSC group and SCCA was higher than that of SCLC group and LSC group. Series analysis of HSP90 伪 NSE CYFRA21-1 could improve the specificity of SCLC. The positive predictive value and correct classification rate were higher than that of HSP90 伪 NSE CYFRA21-1 SCCA and HSP90 伪 CEA, respectively. The correct classification rate was the ideal level. Conclusion HSP90 is an ideal marker for LC screening, and the combined detection of HSP90 伪 and other 5 markers is helpful to the stratified diagnosis of LC.
【作者单位】：四川省人民医院城东病区;
【分类号】：R734.2

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