86例子宫内膜样腺癌附件转移患者的临床病理特征分析

发布时间：2018-05-04 10:35

本文选题：子宫内膜样腺癌 + 附件　；参考：《中国医学科学院学报》2017年03期

【摘要】：目的分析86例子宫内膜样腺癌附件转移患者的临床病理特征。方法回顾性总结2000年1月至2015年12月在中国医学科学院肿瘤医院妇科接受手术治疗的86例子宫内膜样腺癌附件转移患者的临床病理资料,比较大体转移和隐匿性转移患者间的临床病理特征。结果 86例患者占同期子宫内膜样腺癌患者总人数的5.4%(86/1592),平均年龄58.1岁,其中,未绝经13例(15.1%),40岁以下2例(2.3%);手术探查发现附件存在大体转移47例(54.7%),术后病理证实隐匿性转移39例(45.3%);卵巢转移34例(39.5%),输卵管和卵巢转移19例(22.1%),单纯输卵管转移33例(38.4%)。大体转移组和隐匿性转移组患者的雌激素受体(χ2=8.086,P=0.042)和孕激素受体(PR)(χ2=9.149,P=0.026)表达水平差异有统计学意义;其余临床病理特征两组间差异均无统计学意义(P均0.05)。非条件Logistic回归分析结果显示,与无表达组相比,PR低表达组的隐匿性转移发生率是大体转移的6.375倍(P=0.005,95%CI:1.768~22.976),PR高表达组的隐匿性转移发生率是大体转移的3.719倍(P=0.048,95%CI:1.009~13.702)。结论子宫内膜样腺癌附件大体转移患者的PR表达水平明显低于隐匿性转移患者。
[Abstract]:Objective to analyze the clinicopathological features of 86 patients with adnexal metastasis of endometrioid adenocarcinoma. Methods a retrospective review of the clinicopathological data of 86 cases of adnexal metastasis of endometrioid adenocarcinoma in the gynecologic Hospital of the Chinese Academy of Medical Sciences from January 2000 to December 2015 was reviewed and compared with those of the patients with general metastasis and occult metastasis. Results 86 patients accounted for 5.4% (86/1592) of the total number of endometrioid adenocarcinoma in the same period, with an average age of 58.1 years, of which 13 were not Menopause (15.1%), 2 cases (2.3%) under 40 years of age, 47 (54.7%) had been found in the appendages (54.7%), 39 cases (45.3%) were confirmed by pathology after operation, and ovarian metastasis 34 cases (39.5%). 19 cases of oviduct and ovarian metastasis (22.1%) and 33 cases of simple oviduct metastasis (38.4%). The difference of estrogen receptor (x 2=8.086, P=0.042) and progestin receptor (PR) (x 2=9.149, P=0.026) in the general and occult metastasis group was statistically significant, and the other clinicopathological features were not statistically significant between the two groups (P 0.05). The unconditional Logistic regression analysis showed that the incidence of occult metastasis in the PR low expression group was 6.375 times more than that of the gross metastasis (P=0.005,95%CI:1.768~22.976), and the incidence of occult metastasis in the PR high expression group was 3.719 times more than that of the gross metastasis (P=0.048,95%CI: 1.009~13.702). Conclusion the annexes of endometrioid adenocarcinoma were generally transferred. The expression level of PR in patients with metastasis was significantly lower than that in patients with occult metastasis.

【作者单位】：国家癌症中心中国医学科学院北京协和医学院肿瘤医院妇瘤科;国家癌症中心中国医学科学院北京协和医学院肿瘤医院病理科;
【分类号】：R737.33

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