术前血清TSH水平与甲状腺微小乳头状癌发生的相关性研究

发布时间：2018-05-06 16:04

本文选题：促甲状腺激素 + 甲状腺恶性肿瘤　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:研究血清促甲状腺激素(thyroid stimulating hormone,TSH)水平与乳头状甲状腺微癌(papillary thyroid microcarcinoma,PTMC)患者的临床病理学特征间的关系。方法:总结分析从2012年1月至2015年4月在我科第一次接受手术的甲状腺有病变的患者的临床与病理学方面的资料,包括TSH水平、性别、年龄。其中符合入选标准的有806例,术后病理学检查确诊为乳头状甲状腺微癌的病例数为403例,良性甲状腺结节肿瘤病变者(BTN,benign thyroid nodules)为403例,予以回顾性分析所入选病例的病史及临床病理学资料,并比较2组患者术前TSH水平、抗甲状腺球蛋白抗体(thyroid globulin antibody,TGAb)水平以及比较2组患者一般资料(包括:性别、年龄、族别、病灶大小等),最终比较不同TSH水平之间PTMC患者所占比例,对乳头状甲状腺微癌的危险因素进行单因素和多因素的logistic回归分析。结果:甲状腺良性组中男173例,女633例,男:女比例为1:4.30。乳头状甲状腺微癌组中男76例,女327例,男:女比例为1:4.30;良性组男97例,女306例,男:女为1:3.15。2组之间男女构成比例的差异无统计学意义(χ~2=3.246,P=0.072)。2组间年龄差异有统计学意义(Z=-5.855,P=0.001)。乳头状甲状腺微癌和良性甲状腺结节肿瘤2组病例术前TSH水平的差异有统计学意义(Z=-6.233,P=0.001);2组间民族构成的差异有统计学意义(χ2=38.961,P=0.001)。logistic回归分析显示:年龄和TSH水平是乳头状甲状腺微癌的独立危险因素(年龄:OR=0.914,P=0.027;TSH:OR=4.662,P=0.008)。结论:乳头状甲状腺微癌患者血清TSH水平较甲状腺良性结节患者高,血清TSH水平的高低可能与乳头状甲状腺微癌的发生有关,血清TSH是预测乳头状甲状腺微癌风险的指标之一。
[Abstract]:Objective: to study the relationship between serum thyroid stimulating hormone (TSH) levels and clinicopathological features of papillary thyroid carcinomas (PTMCs). Methods: from January 2012 to April 2015, the clinical and pathological data, including TSH level, sex and age, of the patients with thyroid lesions underwent the first operation in our department were summarized and analyzed. Among them, 806 cases met the inclusion criteria, 403 cases were diagnosed as papillary thyroid microcarcinoma by postoperative pathological examination, 403 cases were diagnosed as benign thyroid nodules, and 403 cases were diagnosed as benign thyroid nodules. The history and clinicopathological data of the selected patients were retrospectively analyzed, and the preoperative TSH levels, the levels of thyroid globulin antibody-tGAbs and the general data of the two groups (including sex, age, race) were compared. The proportion of PTMC patients with different TSH levels was compared and the risk factors of papillary thyroid microcarcinoma were analyzed by univariate and multivariate logistic regression analysis. Results: there were 173 males and 633 females in benign thyroid group. The ratio of male to female was 1: 4.30. In the papillary thyroid microcarcinoma group, there were 76 males and 327 females, the ratio of male to female was 1: 4.30; in benign group, there were 97 males, 306 females and 1: 3.15.2 males: females. There were significant differences in preoperative TSH levels between the two groups of patients with papillary thyroid microcarcinoma and benign thyroid nodule tumor. There was a significant difference in ethnic composition between the two groups (蠂 ~ 2 / 38.961p ~ (0.001). Logistic regression analysis showed that age and TSH level were papillary. The independent risk factors of thyroid microcarcinoma (age: 0. 914) and TSH: 4.662 (P = 0. 008). Conclusion: the level of serum TSH in patients with papillary thyroid microcarcinoma is higher than that in patients with benign thyroid nodules. The level of serum TSH may be related to the occurrence of papillary thyroid microcarcinoma. Serum TSH is one of the predictors of the risk of papillary thyroid microcarcinoma.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R736.1

【相似文献】